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Lobenzarit disodium
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Name

Lobenzarit disodium

 EINECS N/A
CAS No. 64808-48-6 Density N/A
PSA 92.29000 LogP 0.88360
Solubility Soluble in water Melting Point 388° (dec)
Formula C14H10 Cl N O4 . 2 Na Boiling Point 481°C at 760 mmHg
Molecular Weight 335.654 Flash Point 244.7°C
Transport Information N/A Appearance N/A
Safety Poison by intravenous, subcutaneous, and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and Cl−. Risk Codes N/A
Molecular Structure Molecular Structure of 64808-48-6 (BENZOIC ACID, 2-[(2-CARBOXYPHENYL)AMINO]-4-CHLORO-, DISODIUM SALT) Hazard Symbols N/A
Synonyms

Benzoicacid, 2-[(2-carboxyphenyl)amino]-4-chloro-, disodium salt (9CI); CCA; Carfenil;Disodium N-(2-carboxyphenyl)-4-chloroanthranilic acid; Lobenzarit disodium;Lobenzarit disodium salt; Lobenzarit sodium

Article Data 1

Lobenzarit disodium Synthetic route

64-17-5

ethanol

63329-53-3

lobenzarit

64808-48-6

Carfenil

Conditions
ConditionsYield
In sodium hydroxide; water
64808-48-6

Carfenil

146664-23-5

[4-chloro-2-(2-hydroxymethyl-phenylamino)-phenyl]-methanol

Conditions
ConditionsYield
With hydrogenchloride; borane-THF; water In tetrahydrofuran at 0 - 20℃;95%
64808-48-6

Carfenil

848128-24-5

3-chloro-12,13-dimethoxy-10,15-dihydro-5H-5-aza-tribenzo[a,d,g]cyclononene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 95 percent / HCl; H2O; BH3*THF / tetrahydrofuran / 0 - 20 °C
2: 68 percent / H2SO4 / various solvent(s) / 0 °C
View Scheme
64808-48-6

Carfenil

3-chloro-12,13-dimethoxy-5-methyl-10,15-dihydro-5H-5-aza-tribenzo[a,d,g]cyclononene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 95 percent / HCl; H2O; BH3*THF / tetrahydrofuran / 0 - 20 °C
2: 68 percent / H2SO4 / various solvent(s) / 0 °C
3: 47 percent / NaH / dimethylsulfoxide / Heating
View Scheme
64808-48-6

Carfenil

[3-(3-chloro-12,13-dimethoxy-10,15-dihydro-5-aza-tribenzo[a,d,g]cyclononen-5-yl)-propyl]-dimethyl-amine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 95 percent / HCl; H2O; BH3*THF / tetrahydrofuran / 0 - 20 °C
2: 68 percent / H2SO4 / various solvent(s) / 0 °C
3: 66 percent / NaH / dimethylsulfoxide / Heating
View Scheme

Lobenzarit disodium Chemical Properties

IUPAC Name: disodium 2-(2-carboxylatoanilino)-4-chlorobenzoate  
Synonyms of Lobenzarit disodium (CAS NO.64808-48-6): Lobenzarit disodium salt ; Lobenzarit sodium [USAN] ; 2-((2-Carboxyphenyl)amino)-4-chlorobenzoic acid disodium salt ; Benzoic acid, 2-((2-carboxyphenyl)amino)-4-chloro-, disodium salt ; CCRIS 8090 ; Disodium 4-chloro-2,2'-iminobenzoate ; Disodium 4-chloro-2,2'-iminodibenzoate ; Lobenzarit sodium ; UNII-7Z9SP74BXF ;
CAS NO: 64808-48-6 
Molecular Formula of Lobenzarit disodium (CAS NO.64808-48-6): C14H8ClNNa2O4 
Molecular Weight: 335.6502  
H bond acceptors: 5
H bond donors: 3
Freely Rotating Bonds: 4
Polar Surface Area: 77.84 Å2
Flash Point: 244.7 °C
Enthalpy of Vaporization of Lobenzarit disodium (CAS NO.64808-48-6): 78.54 kJ/mol
Boiling Point: 481 °C at 760 mmHg
Vapour Pressure: 4.62E-10 mmHg at 25°C
Molecular Structure:

Lobenzarit disodium Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 320mg/kg (320mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: FLUID INTAKE

SKIN AND APPENDAGES (SKIN): HAIR: OTHER		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15, Pg. 4579, 1987.
mouse LD50 intravenous 400mg/kg (400mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15, Pg. 4579, 1987.
mouse LD50 oral 740mg/kg (740mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15, Pg. 4579, 1987.
mouse LD50 subcutaneous 500mg/kg (500mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15, Pg. 4579, 1987.
rat LD50 intraperitoneal 263mg/kg (263mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: FLUID INTAKE

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15, Pg. 4579, 1987.
rat LD50 oral 1150mg/kg (1150mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: FLUID INTAKE

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15, Pg. 4579, 1987.
rat LD50 subcutaneous 314mg/kg (314mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: FLUID INTAKE

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15, Pg. 4579, 1987.

Lobenzarit disodium Safety Profile

Poison by intravenous, subcutaneous, and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and Cl−.

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