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Midazolam maleate salt

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Name

Midazolam maleate salt

EINECS 261-775-0
CAS No. 59467-94-6 Density N/A
PSA 104.78000 LogP 3.47160
Solubility N/A Melting Point 114-117° (solvated)
Formula C18H13ClFN3.C4H4O4 Boiling Point 496.9 °C at 760 mmHg
Molecular Weight 441.846 Flash Point 254.3 °C
Transport Information 3249 Appearance N/A
Safety 36 Risk Codes 22
Molecular Structure Molecular Structure of 59467-94-6 (Midazolam maleate salt) Hazard Symbols HarmfulXn
Synonyms

Midazolam maleate;4H-Imidazo[1,5-a][1,4]benzodiazepine,8- chloro-6-(2-fluorophenyl)-1-methyl-,(2Z)- 2-butenedioate (1:1);Ro 21-3981;4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6- (2-fluorophenyl)-1-methyl-, (Z)-2-butenedioate (1:1);

Article Data 4

Midazolam maleate salt Specification

The CAS register number of Midazolam maleate salt is 59467-94-6. It also can be called as 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine maleate and the IUPAC name about this chemical is (Z)-but-2-enedioic acid; 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine. Classification Code about this chemical are Anesthetic [intravenous] and Drug / Therapeutic Agent. This chemical is harmful if swallowed. When you are using it, wear suitable protective clothing.

Physical properties about Midazolam maleate salt are: (1)ACD/LogP: 3.93; (2)#H bond acceptors: 3 ; (3)#Freely Rotating Bonds: 1; (4)Polar Surface Area: 30.18Å2; (5)Flash Point: 254.3 °C; (6)Enthalpy of Vaporization: 76.47 kJ/mol; (7)Boiling Point: 496.9 °C at 760 mmHg; (8)Vapour Pressure: 5.21E-10 mmHg at 25°C.

Midazolam maleate salt is a short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(O)\C=C/C(=O)O.Fc4ccccc4C/1=N/Cc3cnc(n3c2c\1cc(Cl)cc2)C
(2)InChI: InChI=1/C18H13ClFN3.C4H4O4/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13;5-3(6)1-2-4(7)8/h2-9H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
(3)InChIKey: XYGVIBXOJOOCFR-BTJKTKAUBD
(4)Std. InChI: InChI=1S/C18H13ClFN3.C4H4O4/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13;5-3(6)1-2-4(7)8/h2-9H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
(5)Std. InChIKey: XYGVIBXOJOOCFR-BTJKTKAUSA-N

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 86mg/kg (86mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 2180, 1981.
mouse LD50 oral 760mg/kg (760mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 2180, 1981.