Midazolam maleate

Base Information

• Chemical Name: Midazolam maleate
• CAS No.: 59467-94-6
• Deprecated CAS: 65607-69-4
• Molecular Formula: C18H13ClFN3^.C4H4O4
• Molecular Weight: 441.846
• European Community (EC) Number: 261-775-0
• NSC Number: 313452
• UNII: 77520S18SE
• Wikidata: Q27266551
• NCI Thesaurus Code: C167002
• ChEMBL ID: CHEMBL2106922
• Mol file: 59467-94-6.mol

Synonyms:Dormicum;Hydrochloride, Midazolam;Maleate, Midazolam;Midazolam;Midazolam Hydrochloride;Midazolam Maleate;Ro 21 3981;Ro 21-3981;Ro 213981;Versed

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Midazolam maleate

Chemical Property:

• Melting Point: 114-117° (solvated)
• Boiling Point: 496.9 °C at 760 mmHg
• Flash Point: 254.3 °C
• PSA: 104.78000
• LogP: 3.47160
• Storage Temp.: 2-8°C
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 3
• Exact Mass: 441.0891619
• Heavy Atom Count: 31
• Complexity: 590

Purity/Quality:

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1=NC=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4F.C(=CC(=O)O)C(=O)O
• Isomeric SMILES: CC1=NC=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4F.C(=C\C(=O)O)\C(=O)O
• Recent ClinicalTrials: PROUD Study - Preventing Opioid Use Disorders
• Recent EU Clinical Trials: “FAST ACUTE SEDATION AT INTENSIVE CARE VS. HIGH-DOSE I.V. ANTI-SEIZURE MEDICATION FOR TREATMENT OF NON-CONVULSIVE STATUS EPILEPTICUS - A RANDOMIZED, MULTICENTER TRIAL (FAST TRIAL)”
• Uses: Sedative; ligand GABA receptor benzodiazepine modulatory site
• Therapeutic Function: Anesthetic

Technology Process of Midazolam maleate

There total 6 articles about Midazolam maleate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.5%

maleic acid (110-16-7,26099-09-2) + Midazolam (59467-70-8) → midazolam maleate (59467-94-6)

Guidance literature:

In ethanol; at -15 - 30 ℃; Inert atmosphere;

Reference yield:

7-chloro-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepine-2-carboxaldoxime + acetaldehyde (75-07-0,9002-91-9) + maleic acid (110-16-7,26099-09-2) → midazolam maleate (59467-94-6)

Guidance literature:

In ethanol; dichloromethane; acetic acid; isopropyl alcohol;

Reference yield:

8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid (59468-44-9) → midazolam maleate (59467-94-6)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride; water / ethanol / 3 h / 20 °C

2: 1-methyl-pyrrolidin-2-one / 0.5 h / 200 °C / Microreactor

3: ethanol / -15 - 30 °C / Inert atmosphere

With hydrogenchloride; water; In 1-methyl-pyrrolidin-2-one; ethanol;

upstream raw materials:

acetaldehyde

maleic acid

Midazolam

8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid

Refernces

• 1、 -. "Process for the synthesis of 4H-imidazo[1,5-a][1,4]benzodiazepines, in particular midazolam and salts thereof". Page/Page column 12-13. . Retrieved 2012/01/06.
• 2、 -. "1,2,5-Oxadiazino[5,4-a][1,4]benzodiazepine derivatives". . . Retrieved 2008/06/13.