Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

Oxytetracycline hydrochloride

Related Products

Hot Products

Name

Oxytetracycline hydrochloride

EINECS 218-161-2
CAS No. 2058-46-0 Density ==
PSA 201.85000 LogP 0.25870
Solubility >100 g/L in water Melting Point 180 °C
Formula C22H25ClN2O9 Boiling Point 845.6 °C at 760 mmHg
Molecular Weight 496.901 Flash Point 465.2 °C
Transport Information N/A Appearance Yellow crystalline solid
Safety 36/37/39-26-36 Risk Codes 63-36-36/37/38
Molecular Structure Molecular Structure of 2058-46-0 (Oxytetracycline hydrochloride) Hazard Symbols HarmfulXn, IrritantXi
Synonyms

2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-,monohydrochloride, [4S-(4a,4aa,5a,5aa,6b,12aa)]-;1-Dimethylamino-1,4,6,11,12,13,14,18-octahydro-2,5,7,11,12,14-hexahydroxy-4,6-dioxo-11-methylnaphthacene-3-carbonamidehydrochloride;5-Hydroxytetracycline hydrochloride;5-Hydroxytetracyclinemonohydrochloride;Alamycin;Aquacycline;Duphacycline;Engemycin;Gynamousse;Mepatar;Oxy WS;Oxy-Dumocyclin;Oxybiotic;Oxycyclin;Oxypan;Oxytet;Oxytetrin;TM 5;Terraject;Terramycin hydrochloride;Tetra-Tabilinen;Tetran hydrochloride;Toxinal;Vetilmicin;

Article Data 2

Oxytetracycline hydrochloride Synthetic route

61068-97-1

oxytetracycline 5-sulphosalicylate

2058-46-0

oxytetracycline hydrochloride

Conditions
ConditionsYield
With calcium chloride In methanol at 60℃;80%

cadmium(II) chloride monohydrate

2058-46-0

oxytetracycline hydrochloride

90-02-8

salicylaldehyde

C29H28CdN2O11

Conditions
ConditionsYield
In ethanol for 8h; Reflux;75%
10241-05-1

molybdenum(V) chloride

2058-46-0

oxytetracycline hydrochloride

90-02-8

salicylaldehyde

C29H27Cl2MoN2O11

Conditions
ConditionsYield
In ethanol for 8h; Reflux;65%

thorium(IV) nitrate

2058-46-0

oxytetracycline hydrochloride

oxytetracycline thorium(IV) trichloride hydrochloride tetrahydrate complex

Conditions
ConditionsYield
In ethanol excess of C22H23N2O9*HCl used;
In water excess of C22H23N2O9*HCl used;
In further solvent(s) excess of C22H23N2O9*HCl used, solvent: methyl cellosolve;
548-62-9

crystal violet

2058-46-0

oxytetracycline hydrochloride

crystal violet-oxytetracycline ionic pair

Conditions
ConditionsYield
In ammonia; water pH=9;
2058-46-0

oxytetracycline hydrochloride

A

471-47-6

oxamic acid

B

144-62-7

oxalic acid

C

108-24-7

acetic anhydride

D

110-16-7

maleic acid

E

110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With water; sodium sulfate pH=7; Electrochemical reaction;
2058-46-0

oxytetracycline hydrochloride

124-38-9

carbon dioxide

Conditions
ConditionsYield
With sulfur-doped CoFe2O4 nanopowders In water at 20℃; for 5h; pH=8.5; Kinetics; pH-value; Irradiation;

bismuth (III) nitrate pentahydrate

2058-46-0

oxytetracycline hydrochloride

Reaxys ID: 33826175

Reaxys ID: 33826175

Conditions
ConditionsYield
Stage #1: bismuth (III) nitrate pentahydrate; oxytetracycline hydrochloride In water for 0.5h;
Stage #2: at 160℃; for 16h; Autoclave;
Stage #3: at 350℃; for 3h; Calcination;

bismuth (III) nitrate pentahydrate

2058-46-0

oxytetracycline hydrochloride

A

bismuth (III) oxychloride

B

Reaxys ID: 33826175

Reaxys ID: 33826175

Conditions
ConditionsYield
Stage #1: bismuth (III) nitrate pentahydrate; oxytetracycline hydrochloride In water for 0.5h;
Stage #2: at 160℃; for 16h; Autoclave;
Stage #3: at 300℃; for 3h; Calcination;

Oxytetracycline hydrochloride Chemical Properties

Empirical Formula: C22H25ClN2O9
Molecular Weight: 496.8949 
EINECS: 218-161-2 
Flash Point: 394 °C
Enthalpy of Vaporization: 111.54 kJ/mol
Boiling Point: 727.8 °C at 760 mmHg
Vapour Pressure: 3.09E-22 mmHg at 25°C
Melting point: 180 °C
Storage tempreture: 0-6 °C
Water solubility: >100 g/L
Appearance: Yellow crystalline solid
Structure of Oxytetracycline hydrochloride (CAS NO.2058-46-0):
                        
IUPAC Name: (2Z,4S,4aR,5S,5aR,6S,12aS)-2-[Amino(hydroxy)methylidene]-4-(dimethylamino)-5,6,10,11,12a-pentahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione hydrochloride
Product Category of Oxytetracycline hydrochloride (CAS NO.2058-46-0): Amines;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Antibacterial;Antibiotics;Antibiotics by Application;Chemical Structure Class;Genetic Marker SelectionAntibiotics;Mechanism of Action

Oxytetracycline hydrochloride Uses

 Oxytetracycline hydrochloride (CAS NO.2058-46-0) can be used for antibiotic substance isolated from the elaboration products of the actinomycete, Streptomyces rimosus, grown on a suitable medium.

Oxytetracycline hydrochloride Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 100mg/kg (100mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Annals of the New York Academy of Sciences. Vol. 53, Pg. 238, 1950.
mouse LD50 intravenous 100mg/kg (100mg/kg)   "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967Vol. -, Pg. 490, 1967.
mouse LD50 oral 6696mg/kg (6696mg/kg)   Annals of the New York Academy of Sciences. Vol. 53, Pg. 238, 1950.
mouse LD50 subcutaneous 600mg/kg (600mg/kg)   Annals of the New York Academy of Sciences. Vol. 53, Pg. 245, 1950.
rabbit LDLo intravenous 80mg/kg (80mg/kg) BEHAVIORAL: TREMOR
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: EXCITEMENT
Journal of Pharmacology and Experimental Therapeutics. Vol. 99, Pg. 234, 1950.
rat LD50 intravenous 302mg/kg (302mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 99, Pg. 234, 1950.
rat LD50 subcutaneous 800mg/kg (800mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 9, Pg. 711, 1959.
 

Oxytetracycline hydrochloride Safety Profile

Hazard Codes: HarmfulXn,IrritantXi
Risk Statements: 63-36-36/37/38 
R36:Irritating to eyes. 
R36/37/38:Irritating to eyes, respiratory system and skin. 
R63:Possible risk of harm to the unborn child.
Safety Statements: 36/37/39-26-36 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.

Oxytetracycline hydrochloride Specification

 Oxytetracycline hydrochloride , its cas register number is 2058-46-0. It also can be called 5-Hydroxytetracycline hydrochloride ; Oxytetracycline HCl ; and [4S-(4alpha,4aalpha,5alpha,5aalpha,6beta,12aalpha)]-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride . It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product : If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately. Wash mouth out with water, and get medical aid immediately. Notes to physician: Treat supportively and symptomatically.
In addition,  Oxytetracycline hydrochloride (CAS NO.2058-46-0) is sensitive to light and air, and may discolor on exposure to air and light. It is not compatible with strong oxidizing agents, bases, and you must not take it with incompatible materials, light, exposure to air, exposure to moist air or water. And also prevent it to broken down into hazardous decomposition products: irritating and toxic fumes and gases. hydrogen chloride, carbon monoxide, carbon dioxide.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 2058-46-0