Benzonitrile, 2-iodo-4-nitro-

Base Information

• Chemical Name: Benzonitrile, 2-iodo-4-nitro-
• CAS No.: 300627-43-4
• Molecular Formula: C7H3IN2O2
• Molecular Weight: 274.018
• Hs Code.: 2926907090
• Mol file: 300627-43-4.mol

Synonyms:2-Iodo-4-nitro-benzonitrile;4-nitro-2-iodobenzonitrile;

Chemical Property of Benzonitrile, 2-iodo-4-nitro-

Chemical Property:

• Melting Point: 154 - 155.5 °C (hexane)
• PSA: 69.61000
• LogP: 2.59428

Purity/Quality:

99% ^*data from raw suppliers

2-Iodo-4-nitro-benzonitrile ＞97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzonitrile, 2-iodo-4-nitro-

There total 7 articles about Benzonitrile, 2-iodo-4-nitro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-iodo-4-nitrobenzamide (89677-75-8) → 2-iodo-4-nitrobenzonitrile (300627-43-4)

Guidance literature:

With thionyl chloride; for 3h; Heating;

DOI:10.1021/jm000163y

Reference yield: 61.0%

2-iodo-4-nitrophenylamine (6293-83-0) + copper(l) cyanide → 2-iodo-4-nitrobenzonitrile (300627-43-4)

Guidance literature:

2-iodo-4-nitrophenylamine; copper(l) cyanide; With sulfuric acid; acetic acid; In water; for 0.5h;

With copper(I) nitrite; sodium hydrogencarbonate; sodium nitrite; In water; for 1h;

DOI:10.3390/molecules26092525

Reference yield: 44.0%

2-iodo-4-nitrophenylamine (6293-83-0) + potassium cyanide (151-50-8) → 2-iodo-4-nitrobenzonitrile (300627-43-4)

Guidance literature:

2-iodo-4-nitrophenylamine; With hydrogenchloride; sodium nitrite; at 0 ℃;

With sodium tetrafluoroborate; In water; at 0 ℃;

potassium cyanide; In water; at 22 ℃; Further stages.;

DOI:10.1016/j.bmcl.2008.02.006

upstream raw materials:

2-iodo-4-nitrobenzamide

2-iodo-4-nitrophenylamine

sodium cyanide

4-nitro-2-iodobenzoic acid

Downstream raw materials:

N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-methylpropanamide

Refernces

• 1、 Salvati, Mark E.,Balog, Aaron,Shan, Weifang,Rampulla, Richard,Giese, Soren,Mitt, Tom,Furch, Joseph A.,Vite, Gregory D.,Attar, Ricardo M.,Jure-Kunkel, Maria,Geng, Jieping,Rizzo, Cheryl A.,Gottardis, Marco M.,Krystek, Stanley R.,Gougoutas, Jack,Galella, Michael A.,Obermeier, Mary,Fura, Aberra,Chandrasena, Gamini. "Identification and optimization of a novel series of [2.2.1]-oxabicyclo imide-based androgen receptor antagonists". . p. 1910 - 1915. Retrieved 2008/12/22.
• 2、 Nair, Vipin A.,Mustafa, Suni M.,Mohler, Michael L.,Fisher, Scott J.,Dalton, James T.,Miller, Duane D.. "Synthesis of novel iodo derived bicalutamide analogs". . p. 9475 - 9477. Retrieved 2007/10/03.