(E)-3-Fluorostilbene

Base Information

• Chemical Name: (E)-3-Fluorostilbene
• CAS No.: 3041-81-4
• Molecular Formula: C₁₄H₁₁F
• Molecular Weight: 198.24
• Mol file: 3041-81-4.mol

Synonyms:

Chemical Property of (E)-3-Fluorostilbene

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-Fluorostilbene

There total 26 articles about (E)-3-Fluorostilbene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-fluoro-3-(2-phenylethynyl)benzene (29778-28-7) → (E)-3-fluorostilbene (19466-30-9,88741-06-4,146565-91-5,146565-93-7,3041-81-4)

Guidance literature:

With water; potassium ethyl xanthogenate; In N,N-dimethyl-formamide; at 130 ℃; for 12h; stereoselective reaction; Schlenk technique;

DOI:10.1039/C9CC00128J

Reference yield: 90.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + 1-Fluoro-3-iodobenzene (1121-86-4) → (E)-3-fluorostilbene (19466-30-9,88741-06-4,146565-91-5,146565-93-7,3041-81-4)

Guidance literature:

With potassium carbonate; In water; at 100 ℃; for 7h; Inert atmosphere;

DOI:10.1016/j.molcata.2011.09.002

Reference yield: 89.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + 3-fluorobromobenzene (1073-06-9) → (E)-3-fluorostilbene (19466-30-9,88741-06-4,146565-91-5,146565-93-7,3041-81-4)

Guidance literature:

With tetrabutylammomium bromide; palladium diacetate; silica gel; potassium carbonate; for 0.75h; Neat (no solvent);

DOI:10.1002/aoc.2827

upstream raw materials:

dibromofluoromethane

1-phenylspiro<2.4>hepta-4,6-diene

benzaldehyde

(3-fluorobenzyl)magnesium chloride

Downstream raw materials:

(E)-4-methyl-4′-styryl-1,1-biphenyl

2-Fluor-phenanthren

Refernces

• 1、 Wang, Mei-Ling,Xu, Hui,Li, Han-Yuan,Ma, Biao,Wang, Zhen-Yu,Wang, Xing,Dai, Hui-Xiong. "Mizoroki-Heck Reaction of Unstrained Aryl Ketones via Ligand-Promoted C-C Bond Olefination". supporting information. p. 2147 - 2152. Retrieved 2021/04/05.
• 2、 -. "Method for synthesizing trans-olefin compound". Paragraph 0091-0094. . Retrieved 2020/06/20.