Technology Process of N-[4-({[(6R)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid
There total 28 articles about N-[4-({[(6R)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 98 percent / aq. 1 M HCl / tetrahydrofuran / 2.5 h / 58 °C
2: 91 percent / hydrogen / 10percent Pd-C / dimethylformamide; aq. HCl / 25 h / 2327.2 Torr
4: 1,1'-carbonyl diimidazole / dimethylformamide
With
hydrogenchloride; hydrogen; 1,1'-carbonyldiimidazole;
palladium on activated charcoal;
In
tetrahydrofuran; hydrogenchloride; N,N-dimethyl-formamide;
DOI:10.1021/jo00042a030
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 93 percent / 1 M aq. NaOH -> pH 9.5 / dioxane / 46 h / Ambient temperature
2: 5.01 g / Dess-Martin periodinane, AcOH / CH2Cl2 / 1.17 h / Ambient temperature
3: 2) NaBH3CN / 1) DMF, 0 deg C, 5 min, 2) DMF, 0 deg C, 1 h
4: 98 percent / aq. 1 M HCl / tetrahydrofuran / 2.5 h / 58 °C
5: 91 percent / hydrogen / 10percent Pd-C / dimethylformamide; aq. HCl / 25 h / 2327.2 Torr
7: 1,1'-carbonyl diimidazole / dimethylformamide
With
hydrogenchloride; sodium hydroxide; hydrogen; sodium cyanoborohydride; Dess-Martin periodane; acetic acid; 1,1'-carbonyldiimidazole;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; hydrogenchloride; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00042a030
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 5.01 g / Dess-Martin periodinane, AcOH / CH2Cl2 / 1.17 h / Ambient temperature
2: 2) NaBH3CN / 1) DMF, 0 deg C, 5 min, 2) DMF, 0 deg C, 1 h
3: 98 percent / aq. 1 M HCl / tetrahydrofuran / 2.5 h / 58 °C
4: 91 percent / hydrogen / 10percent Pd-C / dimethylformamide; aq. HCl / 25 h / 2327.2 Torr
6: 1,1'-carbonyl diimidazole / dimethylformamide
With
hydrogenchloride; hydrogen; sodium cyanoborohydride; Dess-Martin periodane; acetic acid; 1,1'-carbonyldiimidazole;
palladium on activated charcoal;
In
tetrahydrofuran; hydrogenchloride; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00042a030