5,10-DiforMyl-5,6,7,8-tetrahydro Folic Acid

Base Information

• Chemical Name: 5,10-DiforMyl-5,6,7,8-tetrahydro Folic Acid
• CAS No.: 98814-60-9
• Molecular Formula: C21H23N7O8
• Molecular Weight: 501.456
• Mol file: 98814-60-9.mol

Synonyms:N-(ambo-5,10-Diformyl-5,6,7,8-tetrahydro-pteroyl)-L-glutaminsaeure;5,10-DIFORMYL-5,6,7,8-TETRAHYDRO FOLIC ACID;N-(ambo-5,10-diformyl-5,6,7,8-tetrahydro-pteroyl)-L-glutamic acid;

Chemical Property of 5,10-DiforMyl-5,6,7,8-tetrahydro Folic Acid

Chemical Property:

• PKA: 3.42±0.10(Predicted)
• PSA: 228.12000
• Density: 1.67±0.1 g/cm3(Predicted)
• LogP: 1.26670

Purity/Quality:

HPLC ≥ 98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5,10-Diformyl-5,6,7,8-tetrahydrofolic acid is a derivative of the coenzyme 5,6,7,8-tetrahydrofolic acid which is essential in primary metabolism for reactions involving the transfer of a one-carbon unit at the formic acid, the formaldehyde or the methanol oxidation levels.

Technology Process of 5,10-DiforMyl-5,6,7,8-tetrahydro Folic Acid

There total 4 articles about 5,10-DiforMyl-5,6,7,8-tetrahydro Folic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Folic acid → (6RS)-5,10-diformyl-5,6,7,8-tetrahydrofolic acid (98814-60-9)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid anhydride / und Hydrieren des Reaktionsprodukts an Platin

2: water; acetic acid anhydride

With water; acetic anhydride;

DOI:10.1021/ja01151a074

Reference yield:

N10-formylfolic acid (134-05-4) → (6RS)-5,10-diformyl-5,6,7,8-tetrahydrofolic acid (98814-60-9)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid anhydride / und Hydrieren des Reaktionsprodukts an Platin und Behandeln der Reaktionsloesung mit wss.NaOH

2: water; acetic acid anhydride

With water; acetic anhydride;

DOI:10.1021/ja01151a074

Reference yield:

folinic acid (58-05-9,22350-60-3,54353-24-1,68538-85-2,73951-54-9) + formic acid (64-18-6) → (6RS)-5,10-diformyl-5,6,7,8-tetrahydrofolic acid (98814-60-9)

Guidance literature:

With water; acetic anhydride;

DOI:10.1021/ja01151a074

upstream raw materials:

folinic acid

formic acid

folic acid

N¹⁰-formylfolic acid

Downstream raw materials:

5,10-methylidyne-5,6,7,8-tetrahydrofolic acid

folinic acid

Refernces

• 1、 Charlton, Peter A.,Young, Douglas W.,Birdsall, Berry,Feeney, James,Roberts, Gordon C. K.. "Stereochemistry of Reduction of the Vitamin Folic acid by Dihydrofolate Reductase". . p. 1349 - 1354. Retrieved 2007/10/02.