4-chloro-7-Methoxyquinoline-6-carboxaMide

Base Information

• Chemical Name: 4-chloro-7-Methoxyquinoline-6-carboxaMide
• CAS No.: 417721-36-9
• Molecular Formula: C11H9ClN2O2
• Molecular Weight: 236.658
• Hs Code.: 2933499090
• Mol file: 417721-36-9.mol

Synonyms:7-methoxy-4-chloro-quinoline-6-carboxamide;4-chloro-7-methoxy-quinoline-6-carboxylic acid amide;QC-5355;6-Quinolinecarboxamide,4-chloro-7-methoxy;

Chemical Property of 4-chloro-7-Methoxyquinoline-6-carboxaMide

Chemical Property:

• Melting Point: >205°C (dec.)
• Boiling Point: 426.7±45.0 °C(Predicted)
• PKA: 15.28±0.30(Predicted)
• PSA: 66.20000
• Density: 1.380±0.06 g/cm3(Predicted)
• LogP: 2.87990
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

4-Chloro-7-methoxy-6-quinolinecarboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Pharmaceutical Intermediates. 4-chloro-7-Methoxyquinoline-6-carboxaMide is used as an intermediate for synthesizing Lenvatinibis.

Technology Process of 4-chloro-7-Methoxyquinoline-6-carboxaMide

There total 1 articles about 4-chloro-7-Methoxyquinoline-6-carboxaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-cyano-3-hydroxy-aniline (67608-58-6) → 4‐chloro‐7‐methoxyquinoline‐6‐carboxamide (417721-36-9)

Guidance literature:

Multi-step reaction with 5 steps

1: tetrabutylammomium bromide; potassium carbonate / N,N-dimethyl-formamide / 9 h / 110 °C

2: ethanol / 6 h / Reflux

3: polyphosphoric acid / 9 h / 100 °C

4: thionyl chloride / 6 h / Reflux

5: acetic acid / water / 23 h / 90 °C

With thionyl chloride; tetrabutylammomium bromide; potassium carbonate; acetic acid; In ethanol; water; N,N-dimethyl-formamide;

Reference yield: 98.8%

4‐chloro‐7‐methoxyquinoline‐6‐carboxamide (417721-36-9) + 4-amino-3-chlorophenol (17609-80-2) → 4?(4?amino?3?chlorophenoxy)?7?methoxyquinoline?6?carboxamide (417722-93-1)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; at 65 - 70 ℃; for 2h; Temperature; Reagent/catalyst; Solvent; Concentration; Inert atmosphere; Large scale;

Reference yield: 98.0%

4‐chloro‐7‐methoxyquinoline‐6‐carboxamide (417721-36-9) + 4-Amino-3-chlorophenol hydrochloride (52671-64-4) → 4-((2-chloro-4-hydroxyphenyl)amino)-7-methoxyquinoline-6-carboxamide

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 70 ℃;

upstream raw materials:

4-cyano-3-hydroxy-aniline

Downstream raw materials:

lenvatinib

4-(4-amino-2-methylphenoxy)-7-methoxyquinoline-6-carboxylic acid amide

6-Carbamoyl-4-(3-fluoro-4-nitrophenoxy)-7-methoxyquinoline

4?(4?amino?3?chlorophenoxy)?7?methoxyquinoline?6?carboxamide

Refernces