417722-93-1

Basic information

• Product Name: 4-(4-aMino-3-chlorophenoxy)-7-Methoxyquinoline-6-carboxaMide
• Synonyms: 4-(4-aMino-3-chlorophenoxy)-7-Methoxyquinoline-6-carboxaMide;Lenvatinib Impurity c;4-(4-amino-3-chlorophenoxy)-7-methoxy-6-Quinolinecarboxamide;4-(3-chloro-4-ureidophenoxy)-7-methoxyquinoline-6-carboxylic acid;Lenvatinib impurity;lenvaim-E;Lenvatinib Intermediates 1
• CAS NO: 417722-93-1
• Molecular Formula: C₁₇H₁₄ClN₃O₃
• Molecular Weight: 343.76436
• EINECS: -0
• Mol File: 417722-93-1.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 577.2±50.0 °C(Predicted)
• Appearance: /
• Density: 1.407±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 15.46±0.30(Predicted)
• CAS DataBase Reference: 4-(4-aMino-3-chlorophenoxy)-7-Methoxyquinoline-6-carboxaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-aMino-3-chlorophenoxy)-7-Methoxyquinoline-6-carboxaMide(417722-93-1)
• EPA Substance Registry System: 4-(4-aMino-3-chlorophenoxy)-7-Methoxyquinoline-6-carboxaMide(417722-93-1)

Safety Data

• Hazardous Substances Data: 417722-93-1(Hazardous Substances Data)

Usage

Description

4-(4-Amino-3-chlorophenoxy)-7-Methoxyquinoline-6-carboxamide is a chemical compound with the molecular formula C16H14ClN3O3. It is an impurity of Lenvatinib (L329400), a drug used in the treatment of various types of cancer. 4-(4-aMino-3-chlorophenoxy)-7-Methoxyquinoline-6-carboxaMide is also utilized in pharmaceutical studies, serving as a reference standard in high-performance liquid chromatography (HPLC) methods for analyzing Lenvatinib or its salt. Its use in these studies contributes to the specificity, accuracy, precision, and high sensitivity of the analysis.

Uses

Used in Pharmaceutical Studies:
4-(4-Amino-3-chlorophenoxy)-7-Methoxyquinoline-6-carboxamide is used as a reference standard in the pharmaceutical industry for the HPLC method. This application is crucial for ensuring the accurate analysis of Lenvatinib or its salt, which is essential for the development and quality control of the drug.
Used in Quality Control of Lenvatinib:
In the pharmaceutical industry, 4-(4-Amino-3-chlorophenoxy)-7-Methoxyquinoline-6-carboxamide is used as a reference standard to ensure the quality and purity of Lenvatinib. This helps in maintaining the drug's efficacy and safety, as well as in the development of new formulations and drug delivery systems.
Used in Analytical Chemistry:
4-(4-Amino-3-chlorophenoxy)-7-Methoxyquinoline-6-carboxamide is used as a reference compound in analytical chemistry, particularly in HPLC methods. Its role in these methods allows for the precise determination of the drug's concentration, purity, and stability, which are vital for the drug's therapeutic effectiveness and safety.

Upstream product

• 417721-36-9 4‐chloro‐7‐methoxyquinoline‐6‐carboxamide 
• 17609-80-2 4-amino-3-chlorophenol 
• 796848-79-8 1-(2-chloro-4-hydroxyphenyl)-3-cyclopropyl urea 
• 417716-92-8 lenvatinib 
• 417724-81-3 7-methoxy-4-oxo-1,4-dihydroquinoline-6-carboxamide 
• 205448-64-2 methyl 4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)-amino)-2-methoxybenzoate 
• 27492-84-8 Methyl 4-amino-2-methoxybenzoate 
• 205448-66-4 methyl 4-chloro-7-methoxyquinoline-6-carboxylate 
• 491-11-2 3-chloro-4-nitrophenol 
• 417721-35-8 7-methoxy-4-chloro-quinoline-6-carbonyl chloride 
• 417721-34-7 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylic acid 
• 205448-65-3 7-methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylic acid methyl ester 
• 52671-64-4 4-Amino-3-chlorophenol hydrochloride 

Downstream Products

• 857890-39-2 4-[3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy]-7-methoxy-6-quinoline-carboxamide methanesulfonate 
• 417722-95-3 {4-[(6-carbamoyl-7-methoxy-4-quinolyl)oxy]-2-chlorophenyl}amino-carboxylic acid phenyl ester 
• 417716-92-8 lenvatinib 
• 417716-91-7 4-(3-Chloro-4-((2-thiazolylamino)carbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide 
• 417716-90-6 4-(3-Chloro-4-((4-fluoroanilino)carbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide 

Relevant articles and documents

Novel method for the synthesis of lenvatinib using 4-nitrophenyl cyclopropylcarbamate and their pharmaceutical salts

4-Nitrophenyl cyclopropylcarbamate was deployed as a novel synthon for the synthesis of anticancer drug lenvatinib. 4-Nitrophenyl cyclopropylcarbamate was prepared by the reaction of 4-nitrophenyl chloroformate and cyclopropyl amine in acetonitrile at room temperature. Furthermore, lenvatinib was synthesized by reacting 4-(4-amino-3-chlorophenoxy)-7-methoxyquinoline-6-carboxamide with 4-nitrophenyl cyclopropylcarbamate in good yields. Apart from the synthesis of lenvatinib, citrate, phosphate, malate and oxalate salts of?lenvatinib were also reported in good yields.

Preparation method of lenvatinib intermediate

The invention discloses a preparation method of a lenvatinib intermediate. The preparation method comprises the following steps: carrying out a nucleophilic substitution reaction among a compound shown as a formula I, a compound shown as a formula II and

Preparation method of high-purity lenvatinib mesylate crystal form C

The invention belongs to the technical field of pharmaceutical chemicals and especially relates to a preparation method of a lenvatinib mesylate crystal form C. According to the method, the conditions of high temperature, acid serving as a solvent and the