1,4-DICHLORO-2-(METHYLSULFONYL)BENZENE

Base Information

• Chemical Name: 1,4-DICHLORO-2-(METHYLSULFONYL)BENZENE
• CAS No.: 66640-63-9
• Molecular Formula: C7H6Cl2O2S
• Molecular Weight: 225.09
• Hs Code.: 2904909090
• Mol file: 66640-63-9.mol

Synonyms:1,4-Dichloro-2-(methylsulfonyl)benzene;2,5-Dichlorophenyl methyl sulfone;Methylsulfonyl-2,5-dichlorobenzene;

Chemical Property of 1,4-DICHLORO-2-(METHYLSULFONYL)BENZENE

Chemical Property:

• Vapor Pressure: 1.69E-05mmHg at 25°C
• Melting Point: 375.4 °C at 760 mmHg
• Refractive Index: 1.555
• Boiling Point: 180.8 °C
• Flash Point: 180.8°C
• PSA: 42.52000
• Density: 1.451 g/cm³
• LogP: 3.47770

Purity/Quality:

98%Min ^*data from raw suppliers

2,5-Dichlorophenyl methyl sulfone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-DICHLORO-2-(METHYLSULFONYL)BENZENE

There total 4 articles about 1,4-DICHLORO-2-(METHYLSULFONYL)BENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

1,4-Dichlor-2-(methylthio)benzol (17733-24-3) → 2,5-dichlorophenyl methyl sulfone (66640-63-9)

Guidance literature:

With dihydrogen peroxide; In water; at 75 ℃; for 12.5h;

DOI:10.1039/c2gc36073j

Reference yield:

2,5-dichlorbenzenethiol (5858-18-4) + methyl iodide (74-88-4) → 2,5-dichlorophenyl methyl sulfone (66640-63-9)

Guidance literature:

With sodium hydroxide; In ethanol; water; at -15 ℃; for 1h; TLC;

DOI:10.1016/0045-6535(95)00331-2

Reference yield:

para-dichlorobenzene (106-46-7,84348-21-0) + Methanesulfonic anhydride (7143-01-3) → 2,5-dichlorophenyl methyl sulfone (66640-63-9)

Guidance literature:

With trifluorormethanesulfonic acid; tris(trifluoromethanesulfonyloxy)boron; at 40 ℃; for 3.5h;

upstream raw materials:

2,5-dichlorbenzenethiol

methyl iodide

para-dichlorobenzene

Methanesulfonic anhydride

Downstream raw materials:

4-chloro-1-methoxy-2-(methylsulfonyl)benzene

2,5-dichloro-3-iodophenylmethylsulfone

2,5-dichloro-3-nitrophenylmethylsulfone

Refernces

• 1、 Olah,Orlinkov,Oxyzoglou,Prakash, G.K. Suria. "Methanesulfonylation of deactivated aromatics with superelectrophilic CH3so2F·3SbF5 and (CH3so2)2O-2CF3so 3H/B(O3SCF3)3 systems". . p. 1573 - 1578. Retrieved 2007/10/03.