(1-Benzyl-4-phenylpiperidin-4-yl)methanamine

Base Information

• Chemical Name: (1-Benzyl-4-phenylpiperidin-4-yl)methanamine
• CAS No.: 84176-77-2
• Molecular Formula: C19H24 N2
• Molecular Weight: 280.413
• Hs Code.: 2933399090
• European Community (EC) Number: 282-344-3
• DSSTox Substance ID: DTXSID60233099
• Nikkaji Number: J333.063J
• Wikidata: Q83114445
• Mol file: 84176-77-2.mol

Synonyms:(1-benzyl-4-phenylpiperidin-4-yl)methanamine;84176-77-2;1-Benzyl-4-phenylpiperidine-4-methylamine;1-(1-benzyl-4-phenylpiperidin-4-yl)methanamine;EINECS 282-344-3;Cambridge id 7040210;SCHEMBL2470240;DTXSID60233099;MFCD03445314;AKOS016008584;SB44071;AM804387;AS-39477;4(aminomethyl)-1-benzyl-4-phenylpiperidine;1-N-Benzyl-4-phenyl-4-aminomethylpiperidine;4-(Aminomethyl)-1-benzyl-4-phenylpiperidine;CS-0208407;FT-0752048;1-(1-Benzyl-4-phenyl-4-piperidinyl)methanamine;EN300-7402697;4-Phenyl-1-(phenylmethyl)-4-piperidinemethanamine;Z2037316946

Chemical Property of (1-Benzyl-4-phenylpiperidin-4-yl)methanamine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 417.461°C at 760 mmHg
• Flash Point: 249.383°C
• PSA: 29.26000
• Density: 1.03g/cm³
• LogP: 3.81730
• Storage Temp.: 2-8°C
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 280.193948774
• Heavy Atom Count: 21
• Complexity: 295

Purity/Quality:

97% ^*data from raw suppliers

(1-Benzyl-4-phenylpiperidin-4-yl)methanamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCC1(CN)C2=CC=CC=C2)CC3=CC=CC=C3

Technology Process of (1-Benzyl-4-phenylpiperidin-4-yl)methanamine

There total 4 articles about (1-Benzyl-4-phenylpiperidin-4-yl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-benzyl-4-cyano-4-phenylpiperidine (56243-25-5) → 1-Benzyl-4-phenylpiperidin-4-yl-methanamin (84176-77-2)

Guidance literature:

1-benzyl-4-cyano-4-phenylpiperidine; With lithium aluminium tetrahydride; In diethyl ether; at 0 - 25 ℃;

With sodium hydrogencarbonate; In diethyl ether;

Reference yield: 55.0%

1-(4-Cyano-4-phenylpiperidin-1-yl)-phenylmethanon → 1-Benzyl-4-phenylpiperidin-4-yl-methanamin (84176-77-2)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether;

DOI:10.1002/ardp.19863190606

Reference yield:

4-phenyl-4-cyanopiperidine (40481-13-8) → 1-Benzyl-4-phenylpiperidin-4-yl-methanamin (84176-77-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent

2: 55 percent / LiAlH₄ / diethyl ether

With lithium aluminium tetrahydride; In diethyl ether;

DOI:10.1002/ardp.19863190606

upstream raw materials:

1-benzyl-4-cyano-4-phenylpiperidine

4-phenyl-4-cyanopiperidine

benzoyl chloride

Downstream raw materials:

1,1-dimethylethyl {[4-phenyl-1-(phenylmethyl)-4-piperidinyl]methyl}carbamate

C₂₁H₂₃F₃N₂O

1-N-Benzyl-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)piperidine

(4-phenyl-[4]piperidylmethyl)-urea

Refernces

• 1、 -. "RENIN INHIBITORS". Page/Page column 131-132. . Retrieved 2008/12/04.
• 2、 -. "DIARYL PIPERIDINE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS". Page/Page column 24. . Retrieved 2008/06/13.