2,3-Dichlorophenylacetonitrile

Base Information

• Chemical Name: 2,3-Dichlorophenylacetonitrile
• CAS No.: 3218-45-9
• Molecular Formula: C8H5Cl2N
• Molecular Weight: 186.04
• Hs Code.: 2926909090
• Mol file: 3218-45-9.mol

Synonyms:Acetonitrile,(2,3-dichlorophenyl)- (7CI,8CI);2,3-Dichlorobenzeneacetonitrile;

Chemical Property of 2,3-Dichlorophenylacetonitrile

Chemical Property:

• Appearance/Colour: white crystalline powder
• Vapor Pressure: 0.00218mmHg at 25°C
• Melting Point: 66-69 °C
• Refractive Index: 1.565
• Boiling Point: 289.6 °C at 760 mmHg
• Flash Point: 125.9 °C
• PSA: 23.79000
• Density: 1.333 g/cm³
• LogP: 3.05948
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol

Purity/Quality:

98% ^*data from raw suppliers

2-(2,3-Dichlorophenyl)acetonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 36/37/39-26-22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-Dichlorophenylacetonitrile

There total 12 articles about 2,3-Dichlorophenylacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

aqueous potassium cyanide + methanesulphonate + 2,3-dichlorobenzyl alcohol (38594-42-2) + tetra(n-butyl)ammonium hydrogen sulfate + methanesulfonyl chloride (124-63-0) → 2,3-dichlorophenylacetonitrile (3218-45-9)

Guidance literature:

With 2-(Dimethylamino)pyridine; triethylamine; In water; toluene; Petroleum ether;

Reference yield: 72.0%

aqueous potassium cyanide + 2,3-dichlorobenzyl alcohol (38594-42-2) + tetra(n-butyl)ammonium hydrogen sulfate + methanesulfonyl chloride (124-63-0) + 2,3-dichlorobenzylaldehyde (6334-18-5) → 2,3-dichlorophenylacetonitrile (3218-45-9)

Guidance literature:

With sodium borohydrid; triethylamine; pyrographite; In methanol; water; acetone; toluene; Petroleum ether;

Reference yield:

sodium cyanide (143-33-9,25596-52-5) + 2,3-dichlorobenzyl chloride (3290-01-5) → 2,3-dichlorophenylacetonitrile (3218-45-9)

Guidance literature:

In dimethyl sulfoxide; at 20 ℃; for 16h;

upstream raw materials:

potassium cyanide

1-(bromomethyl)-2,3-dichlorobenzene

sodium cyanide

2,3-dichlorotoluene

Downstream raw materials:

(2,3-dichlorophenyl)acetic acid

tert-butyl 4-cyano-4-(2,3-dichlorophenyl)piperidine-1-carboxylate

9-benzyloxy-6-(2,3-dichlorobenzyl)-2-isopropyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione

5-benzyloxy-2-(2,3-dichlorobenzyl)-6-hydroxypyrimidine-4-carboxylic acid (2-hydroxyethyl)isopropylamide

Refernces

• 1、 -. "Novel piperidinecarboxamide derivatives, method for preparing same and pharmaceutical compositions containing same". Page/Page column 6; 10. . Retrieved 2010/02/08.
• 2、 Taylor, David C.,Wightman, Frank,Kazakoff, Clem W.. "METABOLISM OF CHLOROPHENYLALANINES IN CROP AND WEED PLANTS IN RELATION TO THE FORMATION OF POTENTIAL HERBICIDAL END PRODUCTS". . p. 51 - 72. Retrieved 2007/10/02.