Multi-step reaction with 7 steps
1: thionyl chloride / 3 h / 0 - 20 °C
2: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran / 2 h / -78 - 20 °C
3: sodium methylate / methanol / 16 h / 0 - 20 °C
4: lithium hydroxide monohydrate / tetrahydrofuran; water / 18 h / Reflux
5: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4 h / 65 °C
6: hydrogenchloride / tetrahydrofuran; water / 1 h / 20 °C
7: triphenylphosphine; diethylazodicarboxylate / dichloromethane / 2 h / 20 °C
With
hydrogenchloride; n-butyllithium; thionyl chloride; lithium hydroxide monohydrate; sodium methylate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; diisopropylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; hexane; dichloromethane; water;