Multi-step reaction with 7 steps
1: ammonium chloride; trimethylaluminum / toluene / 14 h / 5 - 80 °C
2: sodium methylate / methanol / 16 h / 0 - 20 °C
3: lithium hydroxide monohydrate / tetrahydrofuran; water / 18 h / Reflux
4: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4 h / 65 °C
5: hydrogenchloride / tetrahydrofuran; water / 1 h / 20 °C
6: triphenylphosphine; diethylazodicarboxylate / dichloromethane / 2 h / 20 °C
7: hydrogenchloride / water; methanol / 5 h / 20 °C
With
hydrogenchloride; lithium hydroxide monohydrate; trimethylaluminum; sodium methylate; ammonium chloride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; dichloromethane; water; toluene;