6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID

Base Information Edit

Chemical Name:6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID
CAS No.:56305-04-5
Molecular Formula:C₁₄H₁₈O₄
Molecular Weight:250.295
Hs Code.:
Mol file:56305-04-5.mol

Synonyms:6-hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid;2-carboxy-6-hydroxy-2,5,7,8-tetramethylchroman;6-hydroxy-2,2,7,8-tetramethylchroman-2-carboxylic acid;6-hydroxy-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid;

Suppliers and Price of 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Tocris
Trolox ≥98%(HPLC)
100
$ 38.00

AHH
6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic Acid 97%
25g
$ 558.00

Total 3 raw suppliers

Chemical Property of 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID Edit

Chemical Property:

Melting Point:187-189oC(lit.)
PSA：66.76000
LogP:2.48570
Storage Temp.:Refrigerator
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

Trolox ≥98%(HPLC) ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Uses 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid is a freeradical inhibitor, this is a water soluble derivative of vitamin e. Studies indicate it penetrates the skin more effectively than vitamin e, and that as an anti-oxidant it is more effective than BHT. It can be used in moisturizing lotions.

Technology Process of 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID

There total 47 articles about 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.3%

: 86646-83-5
methyl 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylate

: 56305-04-5,53188-07-1
trolox

Guidance literature:: methyl 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylate; With sodium hydroxide; water; In methanol; at 80 ℃; for 2h;

With potassium hydrogensulfate; In methanol; water; at 80 ℃; for 2h;

Reference yield: 97.0%

: 221324-51-2
(S)-6-(benzyloxy)-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid

: 53101-49-8,53174-06-4,53188-07-1,56305-04-5
(S)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; In methanol; for 8h;
DOI:10.1002/chem.201403768

Reference yield: 94.9%

: 70897-17-5
(S)-(+)-3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid methyl ester

: 53101-49-8,53174-06-4,53188-07-1,56305-04-5
(S)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid

Guidance literature:: (S)-(+)-3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid methyl ester; With water; sodium hydroxide; In methanol; at 80 ℃; for 1h; Inert atmosphere;

With potassium hydrogensulfate; water; In methanol; at 60 ℃; pH=5; Product distribution / selectivity;