3-CHLOROBENZHYDROL

Base Information

• Chemical Name: 3-CHLOROBENZHYDROL
• CAS No.: 63012-03-3
• Molecular Formula: C13H11ClO
• Molecular Weight: 218.683
• Hs Code.: 2906299090
• Mol file: 63012-03-3.mol

Synonyms:3-Chlorobenzhydrol;

Chemical Property of 3-CHLOROBENZHYDROL

Chemical Property:

• Vapor Pressure: 2.86E-05mmHg at 25°C
• Melting Point: 40 °C
• Refractive Index: 1.609
• Boiling Point: 342.57 °C at 760 mmHg
• PKA: 13.28±0.20(Predicted)
• Flash Point: 160.981 °C
• PSA: 20.23000
• Density: 1.221 g/cm³
• LogP: 3.42170
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(3-Chlorophenyl)(phenyl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (3-Chlorophenyl)(phenyl)methanol is useful as T cell activators to treat viral infections and proliferative disorders, such as cancer.

Technology Process of 3-CHLOROBENZHYDROL

There total 25 articles about 3-CHLOROBENZHYDROL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

triphenylboroxine (3262-89-3) + m-Chlorobenzaldehyde (587-04-2) → 3-chlorobenzhydrol (63012-03-3)

Guidance literature:

triphenylboroxine; With bis(1,5-cyclooctadiene)nickel⁽⁰⁾; potassium phosphate; 4-chlorobenzophenone; In tetrahydrofuran; at 20 ℃;

m-Chlorobenzaldehyde; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.tetlet.2009.12.033

Reference yield: 78.0%

m-chlorophenyltrimethylsilane (4405-42-9) + benzaldehyde (100-52-7) → 3-chlorobenzhydrol (63012-03-3)

Guidance literature:

With potassium tert-butylate; In N,N,N,N,N,N-hexamethylphosphoric triamide; at 100 ℃; for 4h;

Reference yield: 75.0%

m-Chlorobenzaldehyde (587-04-2) + phenylboronic acid (98-80-6) → 3-chlorobenzhydrol (63012-03-3)

Guidance literature:

With bis(acetylacetonate)nickel(II); potassium carbonate; In toluene; at 180 ℃; for 0.166667h; Microwave irradiation;

DOI:10.1016/j.tetlet.2011.01.147

upstream raw materials:

3-chlorobenzophenone

m-Chlorobenzaldehyde

1,2-bis(3-chlorophenyl)-1,2-diphenylethane-1,2-diol

Phenetole

Downstream raw materials:

3-chlorobenzophenone

(3-Chloro-phenyl)-phenyl-methanol

(-)-(3-chlorophenyl)(phenyl)methanol

1-benzyl-3-chlorobenzene

Refernces

• 1、 Hu, Liangzhen,Hussain, Muhammad Ijaz,Deng, Qingfu,Liu, Qing,Feng, Yangyang,Zhang, Xiaohui,Xiong, Yan. "I2/Li2CO3-promoted cyanation of diarylalcohols through a dual activation process". . p. 308 - 314. Retrieved 2018/12/11.
• 2、 Meng, Li,Su, Jihu,Zha, Zhenggen,Zhang, Li,Zhang, Zhenlei,Wang, Zhiyong. "Direct electrosynthesis of ketones from benzylic methylenes by electrooxidative C-H activation". supporting information. p. 5542 - 5545. Retrieved 2013/05/23.