2,2-Dimethoxycyclohexanol

Base Information

• Chemical Name: 2,2-Dimethoxycyclohexanol
• CAS No.: 63703-34-4
• Molecular Formula: C8H16O3
• Molecular Weight: 160.213
• Hs Code.: 2909498090
• DSSTox Substance ID: DTXSID10402192
• Nikkaji Number: J275.913F
• Mol file: 63703-34-4.mol

Synonyms:2,2-dimethoxycyclohexanol;63703-34-4;2,2-dimethoxycyclohexan-1-ol;2 2-Dimethoxycyclohexanol;MFCD00192060;2,2-Dimethoxy-cyclohexanol;2,2-dimethoxy-cyclohexan-1-ol;SCHEMBL940127;DTXSID10402192;AKOS006227668;2-hydroxy cyclohexanone dimethyl acetal;SB83934;BS-29247;CS-0207908

Chemical Property of 2,2-Dimethoxycyclohexanol

Chemical Property:

• Vapor Pressure: 0.0313mmHg at 25°C
• Refractive Index: n20/D 1.462(lit.)
• Boiling Point: 88-90oC9 mm Hg(lit.)
• Flash Point: 105 °F
• PSA: 38.69000
• Density: 1.072 g/mL at 25oC(lit.)
• LogP: 0.91040
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 160.109944368
• Heavy Atom Count: 11
• Complexity: 121

Purity/Quality:

98% ^*data from raw suppliers

2,2-Dimethoxy-cyclohexanol ^*data from reagent suppliers

Safty Information:

• Statements: 10
• Safety Statements: 16

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1(CCCCC1O)OC

Technology Process of 2,2-Dimethoxycyclohexanol

There total 10 articles about 2,2-Dimethoxycyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methanol (67-56-1) + Sulfuric acid 4-nitro-phenyl ester 2-oxo-cyclohexyl ester → 2,2-dimethoxycyclohexanol (63703-34-4,415679-41-3)

Guidance literature:

With potassium carbonate; In methanol; for 0.25h; Ambient temperature;

DOI:10.1021/jo00352a002

Reference yield: 87.0%

methanol (67-56-1) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 2,2-dimethoxycyclohexanol (63703-34-4,415679-41-3)

Guidance literature:

With iodine; potassium hydroxide; at 0 - 20 ℃;

DOI:10.1016/j.tet.2009.07.040

Reference yield: 85.0%

1-methoxy-cyclohex-1-ene (931-57-7) → 2,2-dimethoxycyclohexanol (63703-34-4,415679-41-3)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In methanol;

DOI:10.1080/00397919808007005

upstream raw materials:

sodium methylate

2-Chlorocyclohexanone

methanol

1-methoxy-cyclohex-1-ene

Downstream raw materials:

2,2-dimethoxycyclohexanone

methyl 6,6-dimethoxyhexanoate

2,2-dimethoxycyclohexyl (trimethylsilyl)acetate

2-methoxycyclohexanone dimethyl acetal

Refernces

• 1、 Louaisil, Nicolas,Rabasso, Nicolas,Fadel, Antoine. "Highly stereoselective synthesis of new α-amino-β-hydroxy six-membered heterocyclic phosphonic acids, serine analogues". scheme or table. p. 8587 - 8595. Retrieved 2009/12/09.
• 2、 Fontenas,Ait-Haddou,Bejan,Balavoine. "The reaction of enaminones with grignard reagents: Synthesis of α,β- unsaturated ketones". . p. 1743 - 1753. Retrieved 2007/10/03.