Xibrom

Base Information Edit

Chemical Name:Xibrom
CAS No.:91714-93-1
Molecular Formula:C15H11BrNNaO3
Molecular Weight:356.151
Hs Code.:
European Community (EC) Number:695-342-6,804-379-0
UNII:8ECV571Y37
DSSTox Substance ID:DTXSID8044206
Wikidata:Q27126510
NCI Thesaurus Code:C65272
RXCUI:47364
ChEMBL ID:CHEMBL3181947
Mol file:91714-93-1.mol

Synonyms:AHR-10282;bromfenac;bromfenac sodium;Duract;ISV-303;sodium bromfenac;Xibrom

Suppliers and Price of Xibrom

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
Bromfenac sodium ≥98% (HPLC)
50mg
$ 278.00

Sigma-Aldrich
Bromfenac sodium ≥98% (HPLC)
10mg
$ 68.20

Crysdot
Bromfenac sodium 97%
50mg
$ 101.00

ChemScene
Bromfenac sodium
10mg
$ 60.00

ChemScene
Bromfenac sodium
100mg
$ 216.00

ChemScene
Bromfenac sodium
50mg
$ 132.00

ChemScene
Bromfenac sodium
200mg
$ 336.00

Cayman Chemical
Bromfenac (sodium salt) ≥99%
50mg
$ 236.00

Cayman Chemical
Bromfenac (sodium salt) ≥99%
10mg
$ 59.00

Biosynth Carbosynth
Bromfenac sodium
100 mg
$ 70.00

Total 66 raw suppliers

Chemical Property of Xibrom Edit

Chemical Property:

Vapor Pressure:1.77E-13mmHg at 25°C
Melting Point:285 °C
Boiling Point:562.2 °C at 760 mmHg
Flash Point:293.8 °C
PSA：83.22000
LogP:2.13590
Storage Temp.:2-8°C
Solubility.:H2O: ≥5mg/mL
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:6
Exact Mass:765.99364
Heavy Atom Count:45
Complexity:361

Purity/Quality:

99%min ^*data from raw suppliers

Bromfenac sodium ≥98% (HPLC) ^*data from reagent suppliers

Safty Information:

Pictogram(s): N
Hazard Codes:N
Statements: 50
Safety Statements: 61

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C(=C1)C(=O)C2=CC=C(C=C2)Br)N)CC(=O)[O-].C1=CC(=C(C(=C1)C(=O)C2=CC=C(C=C2)Br)N)CC(=O)[O-].O.O.O.[Na+].[Na+]
Recent ClinicalTrials:Bromfenac Versus Dexamethasone After Cataract Surgery
Recent EU Clinical Trials:Effectiveness of Periocular drug Injection in CATaract surgery
Recent NIPH Clinical Trials:The effect and the safety with0.1% bromfenac sodium hydrate ophthalmic solution and 0.1% betamethasone sodium phosphate ophthalmic solution in patients with diabetic macular edema.
Description Bromfenac Sodium was launched in the US as a potent, orally-active, long lasting peripheral analgesic with antiinflammatory properties. It is structurally similar to ketoprofen and diclofenac and can be prepared in three steps from 2-amino-4’-bromophenone using Gassman’s oxindole synthesis. Duract’s biological effects are a result of its ability to reduce prostaglandin production through inhibition of cyclooxygenase. As a 4-bromo derivative of Amfenac, this modification increased the duration of analgesic activity and antiinflammatory potency. It was also free of any CNS, cardiovascular or autonomic effects. In comparison, 5 mg of Duract was equipotent to 650 mg of ASA and 25 mg was slightly more potent than 400 mg of Ibuprofen. Bromfenac is an inhibitor of cyclooxygenase 2 (COX-2; IC50 = 6.6 nM) that is selective over COX-1 (IC50 = 210 nM). It inhibits prostaglandin E2 (PGE2; ) production in a rabbit model of LPS-induced eye inflammation. Bromfenac also decreases inflammation following cataract removal in dogs when administered as a 0.9% topical solution on a tapering schedule for 24 weeks. Formulations containing bromfenac have been used in the treatment of postoperative inflammation following cataract surgery.
Uses Bromfenac sodium has been used:to study its ability to bind to melaninin the synthesis of bromfenac indolinone standardto analyze its permeability in porcine conjunctiva
Therapeutic Function Analgesicá Antiinflammatory

Technology Process of Xibrom

There total 20 articles about Xibrom which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: C₁₈H₁₉BrN₂O

: 91714-93-1
bromfenac sodium

Guidance literature:: With potassium permanganate; sodium carbonate; In ethanol; water; at 20 ℃; for 12h; Solvent; Reagent/catalyst;

Reference yield: 96.3%

: 7-(4-bromophenyl)-3-carboxymethylbenzo[c]isoxazole

: 91714-93-1
bromfenac sodium

Guidance literature:: 7-(4-bromophenyl)-3-carboxymethylbenzo[c]isoxazole; With 5%-palladium/activated carbon; hydrogen; In methanol; water; at 25 - 35 ℃; for 4h; under 2250.23 - 3750.38 Torr; Autoclave; Cooling with ether-dry ice;

With sodium hydroxide; In water; at 20 - 25 ℃; for 2h; Reagent/catalyst; Temperature; Pressure;