4-bromo-picolinic acid chloride

Base Information

• Chemical Name: 4-bromo-picolinic acid chloride
• CAS No.: 64197-01-9
• Molecular Formula: C6H3BrClNO
• Molecular Weight: 220.453
• Mol file: 64197-01-9.mol

Synonyms:

Chemical Property of 4-bromo-picolinic acid chloride

Chemical Property:

• PSA: 29.96000
• LogP: 2.22310

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-bromo-picolinic acid chloride

There total 3 articles about 4-bromo-picolinic acid chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-2-picolinic acid (30766-03-1) → 4-bromopyridine-2-carbonyl chloride (64197-01-9)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; for 2h; Heating;

DOI:10.1016/j.bmcl.2006.12.083

Reference yield:

2-Picolinic acid (98-98-6) → 4-bromopyridine-2-carbonyl chloride (64197-01-9)

Guidance literature:

With thionyl chloride; sodium bromide; for 16h; Heating;

DOI:10.1021/ol0476624

Reference yield:

4-bromo-2-methylpyridine (22282-99-1) → 4-bromopyridine-2-carbonyl chloride (64197-01-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium permanganate / water / 80 °C

2: thionyl chloride / 2 h / Inert atmosphere

With potassium permanganate; thionyl chloride; In water;

DOI:10.1016/j.bmc.2015.04.071

upstream raw materials:

2-Picolinic acid

4-bromo-2-picolinic acid

4-bromo-2-methylpyridine

Downstream raw materials:

methyl 4-methoxypicolinate

1-(4-methoxybenzyl)-2-methyl-5,6-dihydropyridone-2-carboxylic acid methyl ester

5-iodo-1-(4-methoxybenzyl)-2-methyl-5,6-dihydropyridone-2-carboxylic acid methyl ester

2-(4-chlorobutyl)-1-(4-methoxybenzyl)-5,6-dihydropyridone-2-carboxylic acid methyl ester

Refernces

• 1、 -. "SPIROCYCLIC COMPOUNDS". Paragraph 0270. . Retrieved 2018/04/21.
• 2、 Su, Ping,Wang, Jinfeng,Shi, Yaling,Pan, Xiaoyan,Shao, Ruili,Zhang, Jie. "Discovery of biphenyl-aryl ureas as novel VEGFR-2 inhibitors. Part 4: Exploration of diverse hinge-binding fragments". . p. 3228 - 3236. Retrieved 2015/08/03.