4-Bromopyridine-2-carboxylic acid

Base Information

• Chemical Name: 4-Bromopyridine-2-carboxylic acid
• CAS No.: 30766-03-1
• Molecular Formula: C6H4BrNO2
• Molecular Weight: 202.007
• Hs Code.: 29339900
• Mol file: 30766-03-1.mol

Synonyms:4-Bromopicolinic acid;

Chemical Property of 4-Bromopyridine-2-carboxylic acid

Chemical Property:

• Appearance/Colour: Fine needles
• Vapor Pressure: 1.97E-05mmHg at 25°C
• Melting Point: 172-174 °C
• Boiling Point: 347.8 °C at 760 mmHg
• PKA: 3.25±0.10(Predicted)
• Flash Point: 164.2 °C
• PSA: 50.19000
• Density: 1.813 g/cm³
• LogP: 1.54230
• Storage Temp.: -20°C Freezer
• Solubility.: Sparingly Soluble in DMSO, Methanol, Water
• Water Solubility.: Sparingly soluble in dimethyl sulfoxide , methanol and water.

Purity/Quality:

99% ^*data from raw suppliers

4-Bromopicolinic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 20/21/22
• Safety Statements: 24/25-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Bromopyridine-2-carboxylic acid is a useful synthetic intermediate 4-Bromopicolinic acid is a useful synthetic intermediate. Also used as a intermediate for agrochemical, pharmaceutical and dyestuff field.

Technology Process of 4-Bromopyridine-2-carboxylic acid

There total 10 articles about 4-Bromopyridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

4-bromo-2-methylpyridine (22282-99-1) → 4-bromo-2-picolinic acid (30766-03-1)

Guidance literature:

With potassium permanganate; In water; at 80 ℃;

DOI:10.1016/j.bmc.2015.04.071

Reference yield: 20.0%

4-bromo-2-cyanopyridine (62150-45-2) → 4-bromo-2-picolinic acid (30766-03-1)

Guidance literature:

4-bromo-2-cyanopyridine; With sodium hydroxide; In water; Reflux;

With hydrogenchloride; In water; at 130 ℃; for 0.333333h; pH=1 - 2;

DOI:10.1016/j.bmc.2020.115610

Reference yield:

methyl 4-bromopyridine-2-carboxylate (29681-42-3) → 4-bromo-2-picolinic acid (30766-03-1)

Guidance literature:

With water; sodium hydroxide; In ethanol; at 20 - 30 ℃; for 0.333333h;

upstream raw materials:

4-bromo-2-methylpyridine

2-methylpyridine N-oxide

2-methyl-4-nitro-pyridine

2-methyl-4-nitropyridine N-oxide

Downstream raw materials:

4-bromo-2-(hydroxymethyl)pyridine

methyl 4-bromopyridine-2-carboxylate

4-bromopyridine-2-carbonyl chloride

2-{[(tert-butyldiphenylsilyl)oxy]methyl}-4-bromopyridine

Refernces

• 1、 Breinbauer, Rolf,Doler, Carina,Fuchs, Elisabeth,Grabner, Gernot F.,Mayer, Nicole,Melcher, Michaela-Christina,Migglautsch, Anna K.,Romauch, Matthias,Schweiger, Martina,Zechner, Rudolf,Zimmermann, Robert. "Structure-activity relationship studies for the development of inhibitors of murine adipose triglyceride lipase (ATGL)". . . Retrieved 2020/07/13.
• 2、 -. "SMALL ORGANIC MOLECULE REGULATORS OF CELL PROLIFERATION". Page/Page column 292-293. . Retrieved 2008/12/05.