Picolinafen

Base Information

• Chemical Name: Picolinafen
• CAS No.: 137641-05-5
• Molecular Formula: C19H12 F4 N2 O2
• Molecular Weight: 376.31
• European Community (EC) Number: 604-030-0,639-953-8
• UNII: VJE2EX3SNN
• DSSTox Substance ID: DTXSID8044339
• Nikkaji Number: J2.724.014C
• Wikidata: Q2092340
• Mol file: 137641-05-5.mol

Synonyms:Picolinafen;137641-05-5;Picolinafen [ISO];UNII-VJE2EX3SNN;VJE2EX3SNN;N-(4-fluorophenyl)-6-[3-(trifluoromethyl)phenoxy]pyridine-2-carboxamide;N-(4-Fluorophenyl)-6-[3-(trifluoromethyl)phenoxy]-2-pyridinecarboxamide;picolinafene;Pico;N-(4-FLUOROPHENYL)-6-(3-(TRIFLUOROMETHYL)PHENOXY)-2-PYRIDINECARBOXAMIDE;PICOLINAFEN [MI];SCHEMBL54805;DTXSID8044339;CHEBI:138736;CS-O-15680;Picolinafen 10 microg/mL in Cyclohexane;Picolinafen 10 microg/mL in Acetonitrile;Picolinafen, PESTANAL(R), analytical standard;J-007048;Q2092340;2-Pyridinecarboxamide, N-(4-fluorophenyl)-6-[3-(trifluoromethyl)phenoxy]-;4'-fluoro-6-[(alpha,alpha,alpha-trifluoro-m-tolyl)oxy]picolinanilide;N-(4-fluorophenyl)-6-(3-trifluoromethylphenoxy)pyridine-2-carboxamide;N-(4-Fluorophenyl)-6-[3-(trifluoromethyl)phenoxy]-pyridine-2-carboxamide;4'-FLUORO-6-(.ALPHA.,.ALPHA.,.ALPHA.-TRIFLUORO-M-TOLYLOXY)PYRIDINE-2-CARBOXANILIDE;4'-fluoro-6-(alpha,alpha,alpha-trifluoro-m-tolyloxy)pyridine-2-carboxanilide;N-(4-Fluorophenyl)-6-(alpha,alpha,alpha-trifluoro-m-tolyloxy)picolinamide, N-(4-Fluorophenyl)-6-[3-(trifluoromethyl)phenoxy]-2-pyridinecarboxamide

Chemical Property of Picolinafen

Chemical Property:

• Vapor Pressure: 1.41E-06mmHg at 25°C
• Melting Point: 107.2-107.6°
• Boiling Point: 399°Cat760mmHg
• PKA: 10.28±0.70(Predicted)
• Flash Point: 195.1°C
• PSA: 51.22000
• Density: 1.394g/cm³
• LogP: 5.35710
• Storage Temp.: 0-6°C
• XLogP3: 4.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 4
• Exact Mass: 376.08349028
• Heavy Atom Count: 27
• Complexity: 495

Purity/Quality:

98%,99%, ^*data from raw suppliers

Picolinafen ^*data from reagent suppliers

Safty Information:

• Pictogram(s): N
• Hazard Codes: N
• Statements: 50/53
• Safety Statements: 60-61

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)OC2=CC=CC(=N2)C(=O)NC3=CC=C(C=C3)F)C(F)(F)F
• Uses: Herbicide.

Technology Process of Picolinafen

There total 17 articles about Picolinafen which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

6-(3-trifluoromethylphenoxy)pyridine-2-carbonyl chloride (178108-94-6) + 4-fluoroaniline (371-40-4) → N-(4-fluorophenyl)-6-(3-trifluoromethylphenoxy)pyridine-2-carboxamide (137641-05-5)

Guidance literature:

With bis(trichloromethyl) carbonate; triethylamine; In dichloromethane; for 3h;

Reference yield: 85.0%

3-Trifluoromethylphenol (98-17-9) + 4-fluoroaniline (371-40-4) → N-(4-fluorophenyl)-6-(3-trifluoromethylphenoxy)pyridine-2-carboxamide (137641-05-5)

Guidance literature:

With potassium carbonate; In ISOPROPYLAMIDE;

Reference yield: 67.0%

2-chloro-6-[3-(trifluoromethyl)phenoxy]pyridine (153564-24-0) + carbon monoxide (201230-82-2) + 4-fluoroaniline (371-40-4) → N-(4-fluorophenyl)-6-(3-trifluoromethylphenoxy)pyridine-2-carboxamide (137641-05-5) + 2-{3-(trifluoromethyl)phenoxy}pyridine (722490-96-2) + N-(4-fluorophenyl)-6-[3-(trifluoromethyl)phenoxy]pyridine-2-amine

Guidance literature:

With sodium carbonate; palladium 10% on activated carbon; 1,4-di(diphenylphosphino)-butane; In xylene; at 200 ℃; for 16h; under 10876.1 Torr; Product distribution / selectivity;

upstream raw materials:

2-chloro-6-[3-(trifluoromethyl)phenoxy]pyridine

carbon monoxide

4-fluoroaniline

P(p-CH₃OC₆H₄)3

Downstream raw materials:

N-(4-fluorophenyl)-5-isopropyl-6-(3-(trifluoromethyl)phenoxy)picolinamide

Refernces

• 1、 -. "Method for preparing picolinafen". Paragraph 0011; 0026; 0030. . Retrieved 2018/10/19.
• 2、 -. "Synthesis method of picolinafen". Paragraph 0016; 0017. . Retrieved 2018/04/01.