178108-94-6

Basic information

• Product Name: 6-(3-trifluoromethylphenoxy)pyridine-2-carbonyl chloride
• Synonyms: 6-(3-trifluoromethylphenoxy)pyridine-2-carbonyl chloride
• CAS NO: 178108-94-6
• Molecular Weight: 301.652
• Mol File: 178108-94-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 6-(3-trifluoromethylphenoxy)pyridine-2-carbonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(3-trifluoromethylphenoxy)pyridine-2-carbonyl chloride(178108-94-6)
• EPA Substance Registry System: 6-(3-trifluoromethylphenoxy)pyridine-2-carbonyl chloride(178108-94-6)

Safety Data

• Hazardous Substances Data: 178108-94-6(Hazardous Substances Data)

Upstream product

• 4684-94-0 6-chloropicolinic acid 
• 98-17-9 3-Trifluoromethylphenol 
• 1929-82-4 nitrapyrin 
• 137640-84-7 6-(3-α,α,α-trifluoromethylphenoxy)picolinic acid 

Downstream Products

• 137641-05-5 N-(4-fluorophenyl)-6-(3-trifluoromethylphenoxy)pyridine-2-carboxamide 

Relevant articles and documents

Method for preparing picolinafen

The invention discloses a method for preparing picolinafen, and belongs to the field of pesticide original medicine technology. The method comprises the following steps that (1) 2-chlorine-6-nitrapyrin serves as a raw material, and acid catalysis hydrolysis is carried out to synthesize 2-chlorine-6-pyridine carboxylic acid; (2) under conditions of alkali 1, catalyst and organic solvent 1, etherification reaction is carried out on 2-chlorine-6-pyridine carboxylic acid and m-trifluoromethylphenol to obtain 2-(3-trifluoromethylphenoxy pendant)-6-picolinic acid; (3) the 2-(3-trifluoromethylphenoxypendant)-6-picolinic acid and di(trichloromethyl) dimethyl carboxylate are reacted in alkali 2 and organic solvent 2 to synthesize intermediate 2-(3-trifluoromethylphenoxy pendant)-6-pyridinecarbonylchloride; (4) the intermediate 2-(3-trifluoromethylphenoxy pendant)-6-pyridinecarbonyl chloride and 4-fluoroaniline are reacted in alkali 3 and organic solvent 2 to prepare the picolinafen. The method for preparing the picolinafen has the advantages that the content of the prepared picolinafen product is 98.1%, the yield of the prepared picolinafen product is 83%, synthesis conditions are mild and safe, the operation process is controlled easily, aftertreatment is simple and convenient, the wastewater quantity is less, and the method is a green synthetic method for preparing the picolinafen.

Synthesis method of picolinafen

The invention provides a synthesis method of picolinafen. The synthesis method comprises the following steps: reacting 2-chloro-6-trichloromethyl pyridine (formula II) with 3-trifluoromethyl phenol (formula III) to generate 2-(3-trifluoromethylphenoxyl)-6