137640-84-7

Basic information

• Product Name: 6-[3-(trifluoromethyl)phenoxy]-2-pyridinecarboxylic acid
• Synonyms: 6-[3-(trifluoromethyl)phenoxy]-2-pyridinecarboxylic acid;Picolinafen acid metabolite;6-(3-(TrifluoroMethyl)phenoxy)picolinic acid;6-(3-(Trifluoromethyl)
• CAS NO: 137640-84-7
• Molecular Formula: C₁₃H₈F₃NO₃
• Molecular Weight: 283.2027296
• Mol File: 137640-84-7.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-[3-(trifluoromethyl)phenoxy]-2-pyridinecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-[3-(trifluoromethyl)phenoxy]-2-pyridinecarboxylic acid(137640-84-7)
• EPA Substance Registry System: 6-[3-(trifluoromethyl)phenoxy]-2-pyridinecarboxylic acid(137640-84-7)

Safety Data

• Hazardous Substances Data: 137640-84-7(Hazardous Substances Data)

Usage

Description

6-[3-(trifluoromethyl)phenoxy]-2-pyridinecarboxylic acid, also known as 6-(3-(trifluoromethyl)phenoxy)picolinic acid, is a chemical compound derived from the breakdown of the pesticide Picolinafen (P436800). It is characterized by its unique molecular structure, which includes a trifluoromethyl group attached to a phenoxy ring, connected to a pyridinecarboxylic acid moiety. 6-[3-(trifluoromethyl)phenoxy]-2-pyridinecarboxylic acid has been detected in crops and water, indicating its presence as a pesticide metabolite.

Uses

Used in Agricultural Industry:
6-[3-(trifluoromethyl)phenoxy]-2-pyridinecarboxylic acid is used as a pesticide metabolite for its role in the breakdown of Picolinafen (P436800). 6-[3-(trifluoromethyl)phenoxy]-2-pyridinecarboxylic acid is significant in the agricultural industry as it can be traced in crops, providing insights into the presence and impact of the parent pesticide on the environment and food safety.
Used in Environmental Monitoring:
In the field of environmental science, 6-[3-(trifluoromethyl)phenoxy]-2-pyridinecarboxylic acid is used as a marker for monitoring the presence and distribution of Picolinafen in water bodies. Its detection in water samples helps assess the extent of pesticide contamination and informs strategies for mitigating the environmental impact of pesticide use.
Used in Regulatory Compliance:
6-[3-(trifluoromethyl)phenoxy]-2-pyridinecarboxylic acid plays a crucial role in ensuring regulatory compliance within the agricultural and environmental sectors. Its analysis in crops and water samples aids in determining whether the levels of pesticide residues are within the acceptable limits set by regulatory authorities, thus safeguarding public health and the environment.

Upstream product

• 4684-94-0 6-chloropicolinic acid 
• 98-17-9 3-Trifluoromethylphenol 
• 1929-82-4 nitrapyrin 
• 178108-83-3 6-[3-(trifluoromethyl)phenoxy] picolinic acid hydrazide 
• 75-87-6 chloral 
• 178108-95-7 2-cyano-6-[3-(trifluoromethyl)phenoxy] pyridine 
• 136227-55-9 methyl-6-(3-α,α,α-trifluoromethylphenoxy)-picolinate 

Downstream Products

• 178108-94-6 6-(3-trifluoromethylphenoxy)pyridine-2-carbonyl chloride 
• 222414-73-5 2-[N-(1-(4'-Cyanobenzyl)-1H-imidazol-5-ylethyl)carbamoyl]-6-(3-trifluoromethylphenoxy)pyridine 

Relevant articles and documents

Method for preparing picolinafen

The invention discloses a method for preparing picolinafen, and belongs to the field of pesticide original medicine technology. The method comprises the following steps that (1) 2-chlorine-6-nitrapyrin serves as a raw material, and acid catalysis hydrolysis is carried out to synthesize 2-chlorine-6-pyridine carboxylic acid; (2) under conditions of alkali 1, catalyst and organic solvent 1, etherification reaction is carried out on 2-chlorine-6-pyridine carboxylic acid and m-trifluoromethylphenol to obtain 2-(3-trifluoromethylphenoxy pendant)-6-picolinic acid; (3) the 2-(3-trifluoromethylphenoxypendant)-6-picolinic acid and di(trichloromethyl) dimethyl carboxylate are reacted in alkali 2 and organic solvent 2 to synthesize intermediate 2-(3-trifluoromethylphenoxy pendant)-6-pyridinecarbonylchloride; (4) the intermediate 2-(3-trifluoromethylphenoxy pendant)-6-pyridinecarbonyl chloride and 4-fluoroaniline are reacted in alkali 3 and organic solvent 2 to prepare the picolinafen. The method for preparing the picolinafen has the advantages that the content of the prepared picolinafen product is 98.1%, the yield of the prepared picolinafen product is 83%, synthesis conditions are mild and safe, the operation process is controlled easily, aftertreatment is simple and convenient, the wastewater quantity is less, and the method is a green synthetic method for preparing the picolinafen.

Synthesis method of picolinafen

The invention provides a synthesis method of picolinafen. The synthesis method comprises the following steps: reacting 2-chloro-6-trichloromethyl pyridine (formula II) with 3-trifluoromethyl phenol (formula III) to generate 2-(3-trifluoromethylphenoxyl)-6

6-(Nonsubstituted or substituted) phenoxy picolinic acids, process of preparing the same, and agricultural/horticultural germicides containing the same

An agricultural or horticultural fungicide containing 6-(unsubstituted or substituted) phenoxy picolinic acid represented by the general formula (I), as an effective ingredient. wherein R is a halogen atom, a C1to C4alkyl group, a C1to C4haloalkyl group, a C1to C4alkoxy group, a C1to C4haloalkoxy group, a C1to C4alkylthio group, a C1to C4alkylamino group, a di(C1to C4alkyl)amino group or a C7to C8aralkyl(C1to C4alkyl)amino group; n2is an integer of 0 to 3; Y is a C1to C4alkyl group, a C1to C4haloalkyl group, a C1to C4alkoxy group, a C1to C4haloalkoxy group, a C1to C4alkylthio group, a C1to C4haloalkylthio group or a halogen atom; and m is an integer of 0 to 5, and when m and n2are not less than 2, Rs and Ys may be the same or different, respectively. The compound is useful as an effective ingredient of agricultural or horticultural fungicides.