4-Fluorophenyl Methanesulfonate

Base Information

• Chemical Name: 4-Fluorophenyl Methanesulfonate
• CAS No.: 72358-72-6
• Molecular Formula: C7H7FO3S
• Molecular Weight: 190.195
• Hs Code.: 2904990090
• Mol file: 72358-72-6.mol

Synonyms:PHENOL, 4-FLUORO-, 1-METHANESULFONATE;4-Fluorophenyl methanesulfonate;4-fluoro-1-methanesulfonyloxybenzene;

Chemical Property of 4-Fluorophenyl Methanesulfonate

Chemical Property:

• Boiling Point: 289.1±32.0 °C(Predicted)
• PSA: 51.75000
• Density: 1.371±0.06 g/cm3(Predicted)
• LogP: 2.24490

Purity/Quality:

99% ^*data from raw suppliers

4-Fluorophenylmethanesulfonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Fluorophenyl Methanesulfonate

There total 3 articles about 4-Fluorophenyl Methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-Fluorophenol (371-41-5) + methanesulfonyl chloride (124-63-0) → methanesulfonic acid 4-fluorophenyl ester (72358-72-6)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 0.25h;

DOI:10.1021/ol049514j

Reference yield: 88.0%

1-fluoro-4-methoxybenzene (459-60-9) + methanesulfonic acid (75-75-2,98527-29-8) → methanesulfonic acid 4-fluorophenyl ester (72358-72-6)

Guidance literature:

1-fluoro-4-methoxybenzene; methanesulfonic acid; at 80 ℃; for 16h;

With phosphorus pentoxide; at 80 ℃; for 2h;

DOI:10.1055/s-0029-1216790

Reference yield:

4-Fluorophenol (371-41-5) + Methanesulfonic anhydride (7143-01-3) → methanesulfonic acid 4-fluorophenyl ester (72358-72-6)

Guidance literature:

With 2,4,6-trimethyl-pyridine; In toluene; at 120 ℃; for 3h;

DOI:10.1021/cs500587b

upstream raw materials:

4-Fluorophenol

methanesulfonyl chloride

1-fluoro-4-methoxybenzene

methanesulfonic acid

Downstream raw materials:

4,4'-difluorobiphenyl

4-Fluorophenol

2-(4-fluorophenyl)benzoxazole

4-fluoro-biphenyl

Refernces

• 1、 Wilson, Daniela A.,Wilson, Christopher J.,Moldoveanu, Costel,Resmerita, Ana-Maria,Corcoran, Patrick,Hoang, Lisa M.,Rosen, Brad M.,Percec, Virgil. "Neopentylglycolborylation of aryl mesylates and tosylates catalyzed by Ni-based mixed-ligand systems activated with Zn". supporting information; experimental part. p. 1800 - 1801. Retrieved 2010/04/24.
• 2、 Ritter, Tobias,Stanek, Kyrill,Larrosa, Igor,Carreira, Erick M.. "Mild cleavage of aryl mesylates: Methanesulfonate as potent protecting group for phenols". . p. 1513 - 1514. Retrieved 2007/10/03.