5-Chloro-1,2,3,4-tetrahydroquinoline

Base Information

• Chemical Name: 5-Chloro-1,2,3,4-tetrahydroquinoline
• CAS No.: 72995-16-5
• Molecular Formula: C₉H₁₀ClN
• Molecular Weight: 167.638
• Hs Code.: 2933499090
• Mol file: 72995-16-5.mol

Synonyms:5-chloro-tetrahydroquinoline;5-chloro-1,2,3,4-tetrahydro-quinoline;5-Chlor-1,2,3,4-tetrahydrochinolin;5-Chloro-1,2,3,4-tetrahydro-quinoline 1HCl salt;Quinoline,5-chloro-1,2,3,4-tetrahydro;

Chemical Property of 5-Chloro-1,2,3,4-tetrahydroquinoline

Chemical Property:

• Boiling Point: 281.9±29.0 °C(Predicted)
• PKA: 4.23±0.20(Predicted)
• PSA: 12.03000
• Density: 1.162±0.06 g/cm3(Predicted)
• LogP: 2.83610

Purity/Quality:

99%,98%, ^*data from raw suppliers

5-Chloro-1,2,3,4-tetrahydroquinoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Chloro-1,2,3,4-tetrahydroquinoline

There total 8 articles about 5-Chloro-1,2,3,4-tetrahydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-chloroquinoline (635-27-8) → 5-chloro-1,2,3,4-tetrahydroquinoline (72995-16-5)

Guidance literature:

With hydrogen; In water; at 20 ℃; for 0.5h; under 760.051 Torr;

Reference yield: 76.0%

3-(2-amino-6-chlorophenyl)-1-propanol → 5-chloro-1,2,3,4-tetrahydroquinoline (72995-16-5)

Guidance literature:

With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; potassium carbonate; In toluene; at 111 ℃; for 40h;

DOI:10.1021/ol026200s

Reference yield: 72.0%

5-chloro-3,4-dihydro-2(1H)-quinolinone (72995-15-4) → 5-chloro-1,2,3,4-tetrahydroquinoline (72995-16-5)

Guidance literature:

With sodium tetrahydroborate; In 1,4-dioxane; at 90 ℃; for 0.5h;

DOI:10.1248/cpb.37.2103

upstream raw materials:

5-chloro-3,4-dihydro-2(1H)-quinolinone

5amino-3,4-dihydro-2(1H)-quinolinone hydrochloride

5-chloroquinoline

4-chloro-1-indanone oxime

Refernces

• 1、 Timelthaler, Daniel,Topf, Christoph. "Heterogeneous Hydrogenation of Quinoline Derivatives Effected by a Granular Cobalt Catalyst". . p. 629 - 642. Retrieved 2021/11/22.
• 2、 Zhang, Sai,Gan, Jie,Xia, Zhaoming,Chen, Xiao,Zou, Yong,Duan, Xuezhi,Qu, Yongquan. "Dual-Active-Sites Design of Co@C Catalysts for Ultrahigh Selective Hydrogenation of N-Heteroarenes". supporting information. p. 2994 - 3006. Retrieved 2020/09/04.