2-(Naphthalen-2-yl)-4,6-diphenylpyrimidine

Base Information

• Chemical Name: 2-(Naphthalen-2-yl)-4,6-diphenylpyrimidine
• CAS No.: 78509-14-5
• Molecular Formula: C26H18N2
• Molecular Weight: 358.442
• DSSTox Substance ID: DTXSID40507523
• Nikkaji Number: J2.123.368D
• Wikidata: Q82363792
• Mol file: 78509-14-5.mol

Synonyms:2-(Naphthalen-2-yl)-4,6-diphenylpyrimidine;78509-14-5;SCHEMBL16302989;DTXSID40507523

Chemical Property of 2-(Naphthalen-2-yl)-4,6-diphenylpyrimidine

Chemical Property:

• XLogP3: 6.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 358.146998583
• Heavy Atom Count: 28
• Complexity: 453

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC(=NC(=N2)C3=CC4=CC=CC=C4C=C3)C5=CC=CC=C5

Technology Process of 2-(Naphthalen-2-yl)-4,6-diphenylpyrimidine

There total 4 articles about 2-(Naphthalen-2-yl)-4,6-diphenylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-naphthalenylmagnesium bromide (21473-01-8) + 2-(methylsulfanyl)-4,6-diphenylpyrimidine (59807-21-5) → 2-Naphthalen-2-yl-4,6-diphenyl-pyrimidine (78509-14-5)

Guidance literature:

With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; In toluene; at 60 ℃; for 4h;

DOI:10.1021/ja044923w

Reference yield: 65.0%

naphthalene-2-boronic acid (32316-92-0) + 2-bromo-4,6-diphenyl-pyrimidine (56181-49-8) → 2-Naphthalen-2-yl-4,6-diphenyl-pyrimidine (78509-14-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; for 24h; Reflux; Inert atmosphere;

Reference yield: 60.0%

β-naphthaldehyde (66-99-9) + 1,3-diphenylpropanedione (120-46-7,61346-73-4) → 2-Naphthalen-2-yl-4,6-diphenyl-pyrimidine (78509-14-5)

Guidance literature:

With 9-molybdo-3-vanadophosphoric acid; ammonium acetate; In acetonitrile; for 6.5h; Reflux;

DOI:10.1016/j.tetlet.2008.11.105

upstream raw materials:

β-naphthaldehyde

1,3-diphenylpropanedione

2-naphthalenylmagnesium bromide

2-(methylsulfanyl)-4,6-diphenylpyrimidine

Refernces

• 1、 Heravi, Majid M.,Sadjadi, Samaheh,Oskooie, Hossein A.,Shoar, Rahim Hekmat,Bamoharram, Fatemeh F.. "A direct oxidative route for the synthesis of pyrimidines using heteropolyacids". scheme or table. p. 662 - 666. Retrieved 2011/03/21.
• 2、 Weis, A. L.,Rosenbach, V.. "A NOVEL CONVENIENT ONE STEP PYRIMIDINE SYNTHESIS". . p. 1453 - 1454. Retrieved 2007/10/02.