Technology Process of 5-Hydroxy-3-(2,4,5-trimethoxyphenyl)-8,8-dimethyl-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one
There total 17 articles about 5-Hydroxy-3-(2,4,5-trimethoxyphenyl)-8,8-dimethyl-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
acetone;
at 55 - 57 ℃;
for 7h;
DOI:10.1248/cpb.36.592
- Guidance literature:
-
In
5,5-dimethyl-1,3-cyclohexadiene;
at 130 ℃;
for 20h;
Overall yield = 80 %; regioselective reaction;
Inert atmosphere;
DOI:10.1002/ejoc.201201339
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 90 percent / K2CO3 / dimethylformamide / 1 h / 140 °C
2: 1.) POCl3 / 1.) 10 deg C, 2.) ClCH2CH2Cl
3: 48 percent / piperidine / ethanol / 6 h / Heating
4: 84 percent / pyridine
5: 1.) thallium(III) nitrate trihydrate, 2.) 10 percent hydrochloric acid / 1.) MeOH, 35 - 36 deg C, 7 h, 2.) MeOH, reflux, 3 h
6: 89 percent / hydrogen / 10 5 palladium/charcoal / methanol; ethyl acetate
7: 51 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / chlorobenzene / 2 h / 140 °C
8: 86 percent / K2CO3 / acetone / 7 h / 55 - 57 °C
With
piperidine; pyridine; hydrogenchloride; thallium(III) nitrate trihydrate; hydrogen; potassium carbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; trichlorophosphate;
palladium on activated charcoal;
In
methanol; ethanol; ethyl acetate; N,N-dimethyl-formamide; chlorobenzene; acetone;
DOI:10.1248/cpb.36.592
