Galdosol

Base Information

• Chemical Name: Galdosol
• CAS No.: 52591-18-1
• Molecular Formula: C20H24O5
• Molecular Weight: 344.408
• ChEMBL ID: CHEMBL4098794
• DSSTox Substance ID: DTXSID301346717
• Nikkaji Number: J9.685G
• Wikidata: Q104398790
• Mol file: 52591-18-1.mol

Synonyms:Galdosol;52591-18-1;(1R,9S,10S)-3,4-dihydroxy-11,11-dimethyl-5-propan-2-yl-16-oxatetracyclo[7.5.2.01,10.02,7]hexadeca-2,4,6-triene-8,15-dione;SCHEMBL4194868;CHEMBL4098794;DTXSID301346717;AKOS040763850;NCGC00385289-01;NCGC00385289-01_C20H24O5_(6beta)-11,12-Dihydroxy-6,20-epoxyabieta-8(14),9(11),12-triene-7,20-dione

Chemical Property of Galdosol

Chemical Property:

• PSA: 83.83000
• LogP: 3.40700
• XLogP3: 4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 344.16237386
• Heavy Atom Count: 25
• Complexity: 611

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)C1=C(C(=C2C(=C1)C(=O)C3C4C2(CCCC4(C)C)C(=O)O3)O)O
• Isomeric SMILES: CC(C)C1=C(C(=C2C(=C1)C(=O)[C@@H]3[C@@H]4[C@@]2(CCCC4(C)C)C(=O)O3)O)O

Technology Process of Galdosol

There total 3 articles about Galdosol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

Oxydesaminoisorosmaricin (80225-53-2) → rosmanol quinone (121927-71-7) + galdosol (52591-18-1)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 2.5h;

DOI:10.1021/np010565o

Reference yield:

carnosol (5957-80-2) → galdosol (52591-18-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / aq. NaHCO₃ / acetone / 6.5 h / 20 °C

2: 21 percent / PCC / CH₂Cl₂ / 2.5 h / 20 °C

With sodium hydrogencarbonate; pyridinium chlorochromate; In dichloromethane; acetone;

DOI:10.1021/np010565o

Reference yield:

carnosic acid (3650-09-7,139236-75-2) → galdosol (52591-18-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / O₂ / acetone / 4 h / 20 °C / 75.01 Torr

2: 72 percent / aq. NaHCO₃ / acetone / 6.5 h / 20 °C

3: 21 percent / PCC / CH₂Cl₂ / 2.5 h / 20 °C

With oxygen; sodium hydrogencarbonate; pyridinium chlorochromate; In dichloromethane; acetone;

DOI:10.1021/np010565o

upstream raw materials:

Oxydesaminoisorosmaricin

carnosol

carnosic acid

Refernces