Bromocyclopentylmagnesium

Base Information

• Chemical Name: Bromocyclopentylmagnesium
• CAS No.: 33240-34-5
• Molecular Formula: C5H9BrMg
• Molecular Weight: 173.335
• Hs Code.: 29319090
• European Community (EC) Number: 251-420-8
• DSSTox Substance ID: DTXSID1067756
• Mol file: 33240-34-5.mol

Synonyms:cyclopentylmagnesium bromide

Chemical Property of Bromocyclopentylmagnesium

Chemical Property:

• Vapor Pressure: 314mmHg at 25°C
• Boiling Point: 49.2ºC at 760mmHg
• Flash Point: −36 °F
• PSA: 0.00000
• Density: 0.996 g/mL at 25 °C
• LogP: 2.74380
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 171.97380
• Heavy Atom Count: 7
• Complexity: 27.3

Purity/Quality:

99.9% ^*data from raw suppliers

Bromocyclopentylmagnesium(2.0?MSolutioninDiethylEther) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F, C
• Hazard Codes: F+,C
• Statements: 12-14-22-34-66-67-19-17
• Safety Statements: 16-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CC[CH-]C1.[Mg+2].[Br-]

Technology Process of Bromocyclopentylmagnesium

There total 3 articles about Bromocyclopentylmagnesium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

Cyclopentyl bromide (137-43-9) → bicyclopentyl (1636-39-1) + cyclopentylmagnesium bromide (33240-34-5)

Guidance literature:

With tetrahydrofuran; magnesium chloride; at 37 ℃; Product distribution; Mechanism; effect of solvent deuteration, other reagents;

DOI:10.1021/ja963208m

Reference yield: 50.0%

Cyclopentyl bromide (137-43-9) → Cyclopentane (287-92-3) + bicyclopentyl (1636-39-1) + cyclopentene (142-29-0) + cyclopentylmagnesium bromide (33240-34-5)

Guidance literature:

With magnesium; In diethyl ether; at 0 ℃; Mechanism; Rate constant; reaction rate dependence on angular velocity of disk, solution viscosity;

DOI:10.1021/ja00408a032

Reference yield:

Cyclopentyl bromide (137-43-9) → cyclopentylmagnesium bromide (33240-34-5)

Guidance literature:

With magnesium; In diethyl ether;

upstream raw materials:

Cyclopentyl bromide

Downstream raw materials:

2-cyclopentyl-ethanol

3-cyclopentyl-1-propanol

Cyclopentyl-phenyl-[2]pyridyl-methanol

phenyl(2-pyridinyl)methanol

Refernces

• 1、 Li, Jie,Ren, Qianyi,Cheng, Xinyi,Karaghiosoff, Konstantin,Knochel, Paul. "Chromium(II)-Catalyzed Diastereoselective and Chemoselective Csp2-Csp3 Cross-Couplings Using Organomagnesium Reagents". supporting information. p. 18127 - 18135. Retrieved 2019/11/19.
• 2、 -. "SYNTHESIS METHOD FOR L-CYCLIC ALKYL AMINO ACID AND PHARMACEUTICAL COMPOSITION HAVING THEREOF". Paragraph 0066-0067. . Retrieved 2016/11/17.