2-Cyclopentylethanol

Base Information

• Chemical Name: 2-Cyclopentylethanol
• CAS No.: 766-00-7
• Molecular Formula: C7H14O
• Molecular Weight: 114.188
• Hs Code.: 2906199090
• European Community (EC) Number: 212-156-9
• DSSTox Substance ID: DTXSID80227399
• Nikkaji Number: J150.137B
• Wikidata: Q72460428
• Mol file: 766-00-7.mol

Synonyms:2-Cyclopentylethanol;766-00-7;Cyclopentaneethanol;2-Cyclopentaneethanol;2-cyclopentylethan-1-ol;2-Cyclopentyl-ethanol;2-Hydroxyethylcyclopentane;2-cyclopentanethanol;EINECS 212-156-9;MFCD00019301;AI3-28619;2-CYCLOPENTYL ETHANOL;Cyclopentylethanol;cyclopentane-ethanol;2-cyclopentyl-1-ethanol;SCHEMBL80485;(2-cyclopentyl)ethyl alcohol;2-(2-Hydroxyethyl)cyclopentane;JEXQWCBPEWHFKC-UHFFFAOYSA-;2-Cyclopentylethanol, AldrichCPR;DTXSID80227399;AMY18681;AKOS005216030;SB23028;AS-50373;SY032290;CS-0055010;FT-0612133;EN300-62842;P10032;A865445;Z397587408

Chemical Property of 2-Cyclopentylethanol

Chemical Property:

• Vapor Pressure: 0.376mmHg at 25°C
• Refractive Index: 1.4585
• Boiling Point: 174.4 °C at 760 mmHg
• PKA: 15.22±0.10(Predicted)
• Flash Point: 70.4 °C
• PSA: 20.23000
• Density: 0.922g/cm³
• LogP: 1.55900
• Storage Temp.: 2-8°C
• Solubility.: Chloroform, DMSO, Methanol
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 114.104465066
• Heavy Atom Count: 8
• Complexity: 55.4

Purity/Quality:

98%,99%, ^*data from raw suppliers

Cyclopentaneethanol ^*data from reagent suppliers

Safty Information:

• Safety Statements: 23-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(C1)CCO
• Uses: Cyclopentaneethanol is used in the prepartion of phenylalanine derivatives for incorporation into peptides as CD4 mimetic miniproteins interacting with HIV-1 surface glycoprotein. It is also used in the preparation of tertiary amine muscarinic receptor antagonists applied towards the treatment of chronic obstructive pulmonary disease.

Technology Process of 2-Cyclopentylethanol

There total 19 articles about 2-Cyclopentylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-cyclopent-2-enyl-ethanol (766-02-9) → 2-cyclopentyl-ethanol (766-00-7)

Guidance literature:

2-cyclopent-2-enyl-ethanol; With pyridinium p-toluenesulfonate; In 1,2-dichloro-ethane; at 80 ℃; for 20h;

With triethylamine; In dichloromethane; at 20 ℃; for 6h;

With trifluoroacetic acid; In methanol; dichloromethane; at 140 ℃; for 0.0666667h; Further stages.; microwave irradiation;

DOI:10.1021/jo0622173

Reference yield: 90.0%

2-cyclopentylacetic acid (1123-00-8) → 2-cyclopentyl-ethanol (766-00-7)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 16h;

Reference yield:

bis(3-cyclopentylpropanoyl) peroxide (955017-60-4) → vinylcyclopentane (3742-34-5) + 2-cyclopentyl-ethanol (766-00-7) + 1,4-dicyclopentylbutane (2980-70-3) + 2-cyclopentylethyl 3-cyclopentylpropanoate (955017-64-8)

Guidance literature:

In hexane; at 80 ℃; Kinetics;

DOI:10.1002/poc.1836

upstream raw materials:

oxirane

cyclopentylmagnesium chloride

cyclopentylmagnesium bromide

2-cyclopent-2-enyl-ethanol

Downstream raw materials:

(2-bromo-ethyl)-cyclopentane

2-cyclopentylethyl chloride

4-Brom-benzolsulfonsaeure-<2-cyclopentyl-ethylester>

methyl-cyclopentane

Refernces

• 1、 Zhao, Siling,Mankad, Neal P.. "Cu-Catalyzed Hydroxymethylation of Unactivated Alkyl Iodides with CO To Provide One-Carbon-Extended Alcohols". supporting information. p. 5867 - 5870. Retrieved 2018/04/17.
• 2、 -. "AZAINDOLE GLUCOKINASE ACTIVATORS". Page/Page column 13. . Retrieved 2011/06/26.