(2-Bromoethyl)cyclopentane

Base Information

• Chemical Name: (2-Bromoethyl)cyclopentane
• CAS No.: 18928-94-4
• Molecular Formula: C7H13Br
• Molecular Weight: 177.084
• Hs Code.: 2903890090
• European Community (EC) Number: 840-081-7
• DSSTox Substance ID: DTXSID60507686
• Wikidata: Q82364052
• Mol file: 18928-94-4.mol

Synonyms:(2-Bromoethyl)cyclopentane;18928-94-4;(2-bromoethyl)-cyclopentane;2-bromoethylcyclopentane;Cyclopentane, (2-bromoethyl)-;beta-cyclopentylethyl bromide;MFCD12405625;2-cyclopen-tylethylbromide;2-(bromoethyl)cyclopentane;(2-bromo-ethyl)-cyclopentane;SCHEMBL261953;DTXSID60507686;GYZRFKCNMIPTEI-UHFFFAOYSA-N;AKOS005216026;AB86640;BS-12934;SY195243;CS-0217808;EN300-85885;C78009;A880460;J-500662

Chemical Property of (2-Bromoethyl)cyclopentane

Chemical Property:

• Vapor Pressure: 1.422mmHg at 25°C
• Boiling Point: 177.131°C at 760 mmHg
• Flash Point: 68.49°C
• PSA: 0.00000
• Density: 1.27g/cm³
• LogP: 2.96160
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 2
• Exact Mass: 176.02006
• Heavy Atom Count: 8
• Complexity: 55.4

Purity/Quality:

98% ^*data from raw suppliers

(2-Bromoethyl)cyclopentane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(C1)CCBr

Technology Process of (2-Bromoethyl)cyclopentane

There total 12 articles about (2-Bromoethyl)cyclopentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-cyclopentyl-ethanol (766-00-7) → (2-bromo-ethyl)-cyclopentane (18928-94-4)

Guidance literature:

With sulfuric acid; hydrogen bromide; for 6h; Heating;

DOI:10.1021/jm00090a017

Reference yield:

ethyl cyclopentylacetate (18322-54-8) → (2-bromo-ethyl)-cyclopentane (18928-94-4)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄ / tetrahydrofuran

2: PBr₃ / diethyl ether; diethyl ether / 16 h / Ambient temperature

With lithium aluminium tetrahydride; phosphorus tribromide; In tetrahydrofuran; diethyl ether;

DOI:10.1248/cpb.40.2391

Reference yield:

2-cyclopentylethyl methanesulfonate (73779-38-1) → (2-bromo-ethyl)-cyclopentane (18928-94-4)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium bromide; In acetone; for 6h; Yield given; Heating;

DOI:10.1021/jm00136a010

upstream raw materials:

2-cyclopentyl-ethanol

2-cyclopentylethyl methanesulfonate

ethyl cyclopentylacetate

ethyl cyclopentylideneacetate

Downstream raw materials:

4-(2-Cyclopentyl-ethoxy)-3,5-dimethoxy-benzoic acid methyl ester

(E)-1-(2-(2-cyclopentylethoxy)-6-hydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one

1-(2-(2-cyclopentylethoxy)-6-hydroxyphenyl)ethanone

N-(4-chlorophenyl)-N-(2-cyclopentylethyl)hydrazine

Refernces

• 1、 -. "SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS". Page 55. . Retrieved 2008/06/13.
• 2、 Yokohama,Miwa,Aibara,Fujiwara,Matsumoto,Nakayama,Iwamoto,Mori,Moroi,Tsukada,Isoda. "Synthesis and antiallergy activity of [1,3,4]thiadiazolo[3,2-a]-1,2,3-triazolo[4,5-d]pyrimidin-9(3H)-one derivatives. II. 6-Alkyl- and 6-cycloalkylalkyl derivatives". . p. 2391 - 2398. Retrieved 2007/10/02.