p-(n-octyl)benzyl broMide

Base Information

• Chemical Name: p-(n-octyl)benzyl broMide
• CAS No.: 88255-11-2
• Molecular Formula: C15H23Br
• Molecular Weight: 283.252
• Mol file: 88255-11-2.mol

Synonyms:p-octylbenzyl bromide;4-octyl benzyl bromide;1-bromomethyl-4-octylbenzene;

Chemical Property of p-(n-octyl)benzyl broMide

Chemical Property:

• PSA: 0.00000
• LogP: 5.48450

Purity/Quality:

99.90% ^*data from raw suppliers

1-(Bromomethyl)-4-octylbenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of p-(n-octyl)benzyl broMide

There total 7 articles about p-(n-octyl)benzyl broMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

4-n-octylbenzenemethanol (40016-25-9) → p-(n-octyl)benzyl bromide (88255-11-2)

Guidance literature:

With phosphorus tribromide; In diethyl ether; at 90 ℃; for 2h;

Reference yield: 28.0%

1,4-bis(bromomethyl)benzene (623-24-5) + n-heptylmagnesium bromide (13125-66-1) → p-(n-octyl)benzyl bromide (88255-11-2)

Guidance literature:

With copper(I) bromide dimethylsulfide complex; In diethyl ether; at 0 ℃; for 18h;

DOI:10.1016/S0040-4039(01)02024-X

Reference yield:

4-octyl-benzoic acid methyl ester (54256-51-8) → p-(n-octyl)benzyl bromide (88255-11-2)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄

2: phosphorus tribromide

With lithium aluminium tetrahydride; phosphorus tribromide;

DOI:10.1246/bcsj.64.2714

upstream raw materials:

4-n-octylbenzenemethanol

1,4-bis(bromomethyl)benzene

n-heptylmagnesium bromide

4-octylbenzoic acid

Downstream raw materials:

(4-octylphenyl)methanamine

5-(N-Cbz-amino)-5-[2-(4-octyloxyphenyl)ethenyl]-2,2-dimethyl-1,3-dioxane

2,2-dimethyl-5-[2-(4-octylphenyl)ethyl]-1,3-dioxan-5-amine

((4-n-Octylphenyl)methyl)triphenylphosphonium bromide

Refernces

• 1、 Feng, Xiangjun,Mei, Yuhua,Luo, Yu,Lu, Wei. "A convenient synthesis of the immunosuppressive agent FTY720". experimental part. p. 161 - 164. Retrieved 2012/07/03.
• 2、 -. "S1P RECEPTORS MODULATORS". Page/Page column 88. . Retrieved 2010/04/30.