3-Flavene

Base Information

• Chemical Name: 3-Flavene
• CAS No.: 6053-99-2
• Molecular Formula: C₁₅H₁₂O
• Molecular Weight: 208.26
• Mol file: 6053-99-2.mol

Synonyms:

Chemical Property of 3-Flavene

Chemical Property:

Purity/Quality:

95+% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Flavene

There total 64 articles about 3-Flavene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

trans-2-phenylvinylboronic acid (6783-05-7) + salicylaldehyde (90-02-8) → 2-phenylchromene (93514-42-2,6053-99-2)

Guidance literature:

With resin-p-C₆H₄-CH₂NHBn; In 1,4-dioxane; at 90 ℃; for 24h;

DOI:10.1021/ol006710r

Reference yield: 94.0%

Dihydroxy-styryl-boran (4363-35-3,6783-05-7,60806-02-2) + salicylaldehyde (90-02-8) → 2-phenylchromene (93514-42-2,6053-99-2)

Guidance literature:

With dibenzylamine; In glycerol; at 90 ℃; for 7h;

DOI:10.1002/open.201402066

Reference yield: 94.0%

C17H16O2 + triphenylindium (3958-47-2) → 2-phenylchromene (93514-42-2,6053-99-2)

Guidance literature:

C₁₇H₁₆O₂; With boron trifluoride diethyl etherate; In tetrahydrofuran; at 0 ℃; for 0.166667h; Inert atmosphere;

triphenylindium; In tetrahydrofuran; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.1021/acs.orglett.6b02058

upstream raw materials:

p-cresol

4α-(2,4,6-trimethylphenoxy)flavan

phenyl 1-phenyl-2-propynyl ether

cis-3-bromoflavan

Downstream raw materials:

flavan-3-ol

3-(2-hydroxy-phenyl)-1-phenyl-propan-1-one

C₁₅H₁₂⁽²⁾H₂O₂

(R)-3,4-dihydro-2-phenyl-2H-1-benzopyran

Refernces

• 1、 Jiang, Ze-Zhen,Gao, Ang,Li, Hao,Chen, Di,Ding, Chang-Hua,Xu, Bin,Hou, Xue-Long. "Enantioselective Synthesis of Chromenes via a Palladium-Catalyzed Asymmetric Redox-Relay Heck Reaction". . p. 3119 - 3122. Retrieved 2017/12/04.
• 2、 Rosholm, Tomi,Gois, Pedro M. P.,Franzen, Robert,Candeias, Nuno R.. "Glycerol as an efficient medium for the Petasis borono-mannich reaction". . p. 39 - 46. Retrieved 2015/03/04.