N-(pyrrole-2-carboxyl)glycine

Base Information

• Chemical Name: N-(pyrrole-2-carboxyl)glycine
• CAS No.: 62409-33-0
• Molecular Formula: C₈H₁₀N₂O₃
• Molecular Weight: 182.179
• Mol file: 62409-33-0.mol

Synonyms:MethylN-[(2-pyrrolyl)carbonyl]glycinate

Chemical Property of N-(pyrrole-2-carboxyl)glycine

Chemical Property:

• Vapor Pressure: 3.55E-08mmHg at 25°C
• Boiling Point: 446.8°C at 760 mmHg
• Flash Point: 224°C
• PSA: 71.19000
• Density: 1.259g/cm³
• LogP: 0.30840

Purity/Quality:

N-(1H-pyrrol-2-ylcarbonyl)-Glycinemethylester 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Methyl N-[(2-Pyrrolyl)carbonyl]glycinate is an intermediate in the synthesis of N-(1H-pyrrol-2-ylcarbonyl)-Glycine (P834600), used as a diagnostic marker of hyperprolinemia type II.

Technology Process of N-(pyrrole-2-carboxyl)glycine

There total 1 articles about N-(pyrrole-2-carboxyl)glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

pyrrol-2-yl trichloromethyl ketone (35302-72-8) + glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) → N-(1H-pyrrol-2-ylcarbonyl)glycine methyl ester (62409-33-0)

Guidance literature:

glycine methylester hydrochloride; With triethylamine; In acetonitrile; at 20 ℃; for 0.166667h; Inert atmosphere;

pyrrol-2-yl trichloromethyl ketone; In acetonitrile; at 82 ℃; Inert atmosphere;

DOI:10.1021/acs.joc.2c00033

upstream raw materials:

pyrrol-2-yl trichloromethyl ketone

glycine ethyl ester hydrochloride

Refernces