Darocur 1174

Base Information

• Chemical Name: Darocur 1174
• CAS No.: 71867-96-4
• Molecular Formula: C10H11ClO2
• Molecular Weight: 198.649
• Mol file: 71867-96-4.mol

Synonyms:2-hydroxy-2-methyl-(p-chloropropiophenone);Dimethyl-<4-chlor-benzoyl>-carbinol;1-(4-Chloro-phenyl)-2-hydroxy-2-methyl-propan-1-one;Dimethyl-(4-chlor-benzoyl)-carbinol;Dimethyl-p-chlorbenzoylcarbinol;1-(4-chlorophenyl)-2-methyl-2-hydroxy-propan-1-one;1-(4'-chlorophenyl)-2-hydroxy-2-methyl-propanone;

Chemical Property of Darocur 1174

Chemical Property:

• Boiling Point: 115-117 °C(Press: 5 Torr)
• PSA: 37.30000
• Density: 1 +-.0.06 g/cm3(Predicted)
• LogP: 2.29360

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Darocur 1174

There total 10 articles about Darocur 1174 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-(4-chlorophenyl)-2-methylpropan-1-one (18713-58-1) → 1-(4-chlorophenyl)-2-hydroxy-2-methylpropan-1-one (71867-96-4)

Guidance literature:

With N-Bromosuccinimide; dimethyl sulfoxide; at 100 ℃; for 24h;

DOI:10.1021/ol5037387

Reference yield: 66.0%

1-(4'-chlorophenyl)-2-methyl-1-propanol (10400-18-7) → 1-(4-chlorophenyl)-2-hydroxy-2-methylpropan-1-one (71867-96-4)

Guidance literature:

1-(4'-chlorophenyl)-2-methyl-1-propanol; With iodine; acetone; In 1,4-dioxane; at 20 ℃; for 0.0833333h;

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In 1,4-dioxane; at 80 ℃; for 30h;

DOI:10.1039/c7cc05697d

Reference yield:

2-phenylsulfonyl-2-methyl-1-(4-chlorophenyl)-1-propanone → 1-(4-chlorophenyl)-2-methylpropan-1-one (18713-58-1) + 1-(4-chlorophenyl)-2-hydroxy-2-methylpropan-1-one (71867-96-4)

Guidance literature:

With 1,3-dimethyl-2-(2-hydroxy-1-naphthyl)benzimidazoline; In dimethyl sulfoxide; at 20 ℃; for 4h; Solvent; Irradiation;

DOI:10.1021/acs.joc.0c02666

upstream raw materials:

1-(4-chlorophenyl)-2-methyl-2-trimethylsilyloxy-propan-1-one

3-(4-chlorophenyl)-2,2-dimethyloxirane

1-(4-chloro-phenyl)-2-methyl-propane-1,2-diol

1-(4-chlorophenyl)-2-methylpropan-1-one

Downstream raw materials:

2-hydroxy-2-methyl-1-(4-(methylthio)phenyl)-propan-1-one

Refernces

• 1、 -. "Monosubstituted and polysubstituted functional group aromatic ketone compounds, and preparation method and photopolymerization initiator thereof". Paragraph 0046-0050. . Retrieved 2022/01/08.
• 2、 Guha, Somraj,Kazi, Imran,Mukherjee, Pranamita,Sekar, Govindasamy. "Halogen-bonded iodonium ion catalysis: A route to α-hydroxy ketones: Via domino oxidations of secondary alcohols and aliphatic C-H bonds with high selectivity and control". supporting information. p. 10942 - 10945. Retrieved 2017/10/13.