3-Aminopyridine-2-sulfonamide

Base Information

• Chemical Name: 3-Aminopyridine-2-sulfonamide
• CAS No.: 94527-46-5
• Molecular Formula: C5H7N3O2S
• Molecular Weight: 173.19300
• European Community (EC) Number: 820-703-3
• Mol file: 94527-46-5.mol

Synonyms:3-aminopyridine-2-sulfonamide;94527-46-5;SCHEMBL390770;3-aminopyridin-2-ylsulfonamide;3-aminopyridine-2- sulfonamide;(3-amino-pyrid-2-yl)sulfonamide;PGTKYSKJIJPEMY-UHFFFAOYSA-N;GS1179;3-AMINO-2-PYRIDINESULFONAMIDE;AKOS027419563;3-amino-pyridine-2-sulfonic acid amide;EN300-276712;G62861;Z1216838238

Chemical Property of 3-Aminopyridine-2-sulfonamide

Chemical Property:

• PSA: 107.45000
• LogP: 1.67350
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 173.02589765
• Heavy Atom Count: 11
• Complexity: 220

Purity/Quality:

99%min ^*data from raw suppliers

3-aminopyridine-2-sulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=C(N=C1)S(=O)(=O)N)N

Technology Process of 3-Aminopyridine-2-sulfonamide

There total 6 articles about 3-Aminopyridine-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

3-nitropyridine-2-sulfonamide (75903-50-3) → 3-aminopyridine-2-sulfonamide (94527-46-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 50 ℃; for 16h; under 760.051 Torr;

Reference yield: 80.0%

3-nitro-2-mercaptopyridine (38240-29-8) → (3-aminopyrid-2-yl)sulfonamide + 3-aminopyridine-2-sulfonamide (94527-46-5)

Guidance literature:

Reference yield:

benzyl 3-nitro-2-pyridyl sulfide (69212-31-3) → 3-aminopyridine-2-sulfonamide (94527-46-5)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid; 1,3-dichloro-5,5-dimethylhydantoin / dichloromethane; water / 0 - 25 °C

2: ammonium hydroxide / dichloromethane; water / 0.17 h / 0 °C

3: ammonium chloride; iron / ethanol; water / 1.5 h / 105 °C

With ammonium hydroxide; 1,3-dichloro-5,5-dimethylhydantoin; iron; ammonium chloride; acetic acid; In ethanol; dichloromethane; water;

upstream raw materials:

3-nitro-2-mercaptopyridine

benzyl 3-nitro-2-pyridyl sulfide

2-Chloro-3-nitropyridine

3-nitropyridine-2-sulfonylchloride

Downstream raw materials:

(1R,2S,7R,8S)-5-(1,1-dioxo-1,4-dihydro-1λ6-thia-2,4,8-triazanaphthalen-3-yl)-3-(4-fluorobenzyl)-6-hydroxy-3-azatricyclo[6.2.1.02,7]undec-5-en-4-one

3-METHYL-4H-PYRIDO[3,2-e][1,2,4]THIADIAZINE 1,1-DIOXIDE

2-METHYL-2,3-DIHYDRO-4H-PYRIDO[3,2-e][1,2,4]THIADIAZINE 1,1-DIOXIDE

3-amino-pyridothiadiazine-1,1-dioxide

Refernces

• 1、 -. "5,6-DIHYDRO-1H-PYRIDIN-2-ONE COMPOUNDS". . . Retrieved 2008/12/04.
• 2、 -. "Anti-infective agents". . . Retrieved 2008/06/13.