2-(BENZYLTHIO)-3-NITROPYRIDINE

Base Information

• Chemical Name: 2-(BENZYLTHIO)-3-NITROPYRIDINE
• CAS No.: 69212-31-3
• Molecular Formula: C12H10N2O2S
• Molecular Weight: 246.29
• Hs Code.: 2933399090
• Mol file: 69212-31-3.mol

Synonyms:2-(Benzylthio)-3-nitropyridine;3-Nitro-2-benzylsulfanylpyridine;

Chemical Property of 2-(BENZYLTHIO)-3-NITROPYRIDINE

Chemical Property:

• Vapor Pressure: 4.45E-06mmHg at 25°C
• Melting Point: 70-72 °C
• Refractive Index: 1.653
• Boiling Point: 394.6 °C at 760 mmHg
• Flash Point: 192.4 °C
• PSA: 84.01000
• Density: 1.32 g/cm³
• LogP: 3.80530

Purity/Quality:

99% ^*data from raw suppliers

2-(Benzylthio)-3-nitropyridine 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(BENZYLTHIO)-3-NITROPYRIDINE

There total 9 articles about 2-(BENZYLTHIO)-3-NITROPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) + phenylmethanethiol (100-53-8) → benzyl 3-nitro-2-pyridyl sulfide (69212-31-3)

Guidance literature:

With TEA; In methanol; for 5h; Heating;

DOI:10.1055/s-1994-25394

Reference yield: 91.0%

3-nitro-2-mercaptopyridine (38240-29-8) + benzyl bromide (100-39-0) → benzyl 3-nitro-2-pyridyl sulfide (69212-31-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield: 85.0%

2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) + S-benzyl O-ethylxanthate (2943-26-2) → benzyl 3-nitro-2-pyridyl sulfide (69212-31-3)

Guidance literature:

With caesium carbonate; In methanol; at 70 ℃; Solvent; Reagent/catalyst; Temperature; Catalytic behavior; Sealed tube;

DOI:10.1002/ejoc.202100647

upstream raw materials:

2-Chloro-3-nitropyridine

phenylmethanethiol

potassium carbonate

benzyl chloride

Downstream raw materials:

2-(benzylthio)pyridin-3-amine

(1R,2S,7R,8S)-5-(1,1-dioxo-1,4-dihydro-1λ6-thia-2,4,8-triazanaphthalen-3-yl)-3-(4-fluorobenzyl)-6-hydroxy-3-azatricyclo[6.2.1.02,7]undec-5-en-4-one

3-aminopyridine-2-sulfonamide

Boc-D-Pen(Npys)-OH

Refernces

• 1、 -. "FUSED [1,2,4]THIADIAZINE DERIVATIVES WHICH ACT AS KAT INHIBITORS OF THE MYST FAMILY". Page/Page column 55. . Retrieved 2019/03/17.
• 2、 -. "PYRIDINYL AND PYRIMIDINYL SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS". Paragraph 0133; 0134; 0135. . Retrieved 2014/09/30.