BOC-PEN(NPYS)-OH

Base Information

• Chemical Name: BOC-PEN(NPYS)-OH
• CAS No.: 250375-03-2
• Molecular Formula: C₁₅H₂₁N₃O₆S₂
• Molecular Weight: 403.48
• Mol file: 250375-03-2.mol

Synonyms:BOC-S-(3-NITRO-2-PYRIDINESULFENYL)-L-PENICILLAMINE;BOC-PEN(NPYS)-OH;BOC-PENICILLAMINE(NPYS)-OH;BOC-BETA,BETA-DIMETHYL-L-CYS(NPYS)-OH;BOC-BETA,BETA-DIMETHYL-CYS(NPYS)-OH

Chemical Property of BOC-PEN(NPYS)-OH

Chemical Property:

• PSA: 184.94000
• LogP: 4.40070
• Storage Temp.: -15°C

Purity/Quality:

97% ^*data from raw suppliers

Boc-Pen (NPys)-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of BOC-PEN(NPYS)-OH

There total 4 articles about BOC-PEN(NPYS)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3-nitro-2-pyridinesulfenyl chloride (68206-45-1) + Boc-DPen(MBzl)-OH (106306-57-4) → Boc-D-Pen(Npys)-OH (250375-03-2,153815-23-7)

Guidance literature:

In dichloromethane; for 0.75h;

DOI:10.1055/s-1994-25394

Reference yield:

2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) → Boc-D-Pen(Npys)-OH (250375-03-2,153815-23-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / TEA / methanol / 4 h / Heating

2: SO₂Cl₂ / CH₂Cl₂ / 0.33 h

3: 70 percent / CH₂Cl₂ / 0.75 h

With sulfuryl dichloride; TEA; In methanol; dichloromethane;

DOI:10.1055/s-1994-25394

Reference yield:

benzyl 3-nitro-2-pyridyl sulfide (69212-31-3) → Boc-D-Pen(Npys)-OH (250375-03-2,153815-23-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / SO₂Cl₂, pyridine / 1,2-dichloro-ethane / 1 h

2: 70 percent / CH₂Cl₂ / 0.75 h

With pyridine; sulfuryl dichloride; In dichloromethane; 1,2-dichloro-ethane;

DOI:10.1055/s-1994-25394

upstream raw materials:

3-nitro-2-pyridinesulfenyl chloride

Boc-^DPen(MBzl)-OH

2-Chloro-3-nitropyridine

benzyl 3-nitro-2-pyridyl sulfide

Refernces