1-(2,4-DICHLORO-PHENYL)-ETHYLAMINE

Base Information

• Chemical Name: 1-(2,4-DICHLORO-PHENYL)-ETHYLAMINE
• CAS No.: 52516-13-9
• Molecular Formula: C8H9Cl2N
• Molecular Weight: 190.072
• Hs Code.: 29349990
• Mol file: 52516-13-9.mol

Synonyms:Phenethylamine,2,4-dichloro- (6CI);2,4-Dichlorophenethylamine;2-(2,4-Dichlorophenyl)ethylamine;

Chemical Property of 1-(2,4-DICHLORO-PHENYL)-ETHYLAMINE

Chemical Property:

• Appearance/Colour: clear colorless to yellow liquid
• Vapor Pressure: 0.0155mmHg at 25°C
• Refractive Index: n20/D 1.5651(lit.)
• Boiling Point: 314.427 °C at 760 mmHg
• PKA: 9.21±0.10(Predicted)
• Flash Point: 114.927 °C
• PSA: 26.02000
• Density: 1.269 g/cm³
• LogP: 3.19490

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,4-Dichlorophenethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,T
• Hazard Codes: Xi,T
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,4-Dichlorophenethylamine may be used in the synthesis of cis-(L-Arginyl)amino-N-(2,4-dichlorophenylmethyl)-L-proline 2,4-dichlorophenethylamide. It may be used in the synthesis of various N-alkylglycine.

Technology Process of 1-(2,4-DICHLORO-PHENYL)-ETHYLAMINE

There total 5 articles about 1-(2,4-DICHLORO-PHENYL)-ETHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,4-Dichlorophenylacetonitrile (6306-60-1) → 2-(2,4-dichloro-phenyl)-ethylamine (52516-13-9)

Guidance literature:

With ammonium hydroxide; hydrogen; In methanol; at 20 ℃; under 1500.15 - 2250.23 Torr;

Reference yield: 90.9%

2,4-dichloro-1-(2-nitrovinyl)benzene (34209-97-7,18984-21-9) → 2-(2,4-dichloro-phenyl)-ethylamine (52516-13-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 5 ℃; for 12h; Inert atmosphere;

Reference yield: 40.0%

2,4-dichlorophenylethylcarbamic acid methyl ester (1403029-66-2) → 5,7-dichloro-3,4-dihydro-2H-isoquinolin-1-one (885273-81-4) + 2-(2,4-dichloro-phenyl)-ethylamine (52516-13-9)

Guidance literature:

With trifluorormethanesulfonic acid; at 0 - 70 ℃; for 45h;

DOI:10.1021/jo3020566

upstream raw materials:

2,4-Dichlorophenylacetonitrile

2,4-dichlorophenylethylcarbamic acid methyl ester

2,4-dichloro-1-(2-nitrovinyl)benzene

2,4-dichlorobenzaldeyhde

Downstream raw materials:

3-(2,4-dichloro-phenethyl)-5-(2-diethylamino-ethyl)-[1,3,5]thiadiazinane-2-thione

N-[2-(2,4-dichlorophenyl)ethyl]-4-fluoro-3-nitrobenzamide

2,4-dichlorophenylethylcarbamic acid methyl ester

C₃₉H₃₈Cl₄N₄O₄

Refernces

• 1、 -. "Synthesis method of lifitegrast intermediate 5,7-dichloro-1,2,3,4-tetrahydroisoquinoline". Paragraph 0070-0073. . Retrieved 2020/05/05.
• 2、 Kurouchi, Hiroaki,Kawamoto, Kyoko,Sugimoto, Hiromichi,Nakamura, Satoshi,Otani, Yuko,Ohwada, Tomohiko. "Activation of electrophilicity of stable Y-delocalized carbamate cations in intramolecular aromatic substitution reaction: Evidence for formation of diprotonated carbamates leading to generation of isocyanates". . p. 9313 - 9328,16. Retrieved 2012/12/11.