2-PICOLINYL HYDRAZIDE

Base Information

• Chemical Name: 2-PICOLINYL HYDRAZIDE
• CAS No.: 1452-63-7
• Molecular Formula: C6H7 N3 O
• Molecular Weight: 137.141
• Hs Code.: 29333990
• Mol file: 1452-63-7.mol

Synonyms:Picolinicacid, hydrazide (6CI,7CI,8CI); 2-(Hydrazinocarbonyl)pyridine;2-Pyridinecarboxylic hydrazide; 2-Pyridylcarboxylic acid hydrazide; INHd 2; NSC81875; Picolinic hydrazide; Picolinoyl hydrazide; Picolinoylhydrazine;Pyridine-2-carbohydrazide; WS 104; a-Picolinohydrazide

Chemical Property of 2-PICOLINYL HYDRAZIDE

Chemical Property:

• Melting Point: 100°C
• Boiling Point: °Cat760mmHg
• PKA: 11.29±0.10(Predicted)
• Flash Point: °C
• PSA: 68.01000
• Density: 1.244g/cm³
• LogP: 0.77630
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Isoniazid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Pyridine-2-carboxylic acid hydrazide is an impurity of Isoniazid (I821450), which is an antibiotic for treatment of Mycobacterium tuberculosis and inhibits mycolic acid biosynthesis. Intermediate used for the synthesis of analogs of antitumor agent 1-acetyl-2-picolinoylhydrazine.

Technology Process of 2-PICOLINYL HYDRAZIDE

There total 16 articles about 2-PICOLINYL HYDRAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl pyridine-2-carboxylate (2459-07-6,260998-83-2) → picolinic acid hydrazide (1452-63-7)

Guidance literature:

With hydrazine hydrate; In ethanol; for 1h; Reflux;

Reference yield: 93.0%

ethyl-2-picolinate (2524-52-9,1228273-66-2) → picolinic acid hydrazide (1452-63-7)

Guidance literature:

With hydrazine hydrate; In ethanol; at 80 ℃; for 4h;

Reference yield: 84.0%

2-Picolinic acid (98-98-6) → picolinic acid hydrazide (1452-63-7)

Guidance literature:

2-Picolinic acid; With dicyclohexyl-carbodiimide; In acetonitrile; at 0 - 20 ℃;

With benzotriazol-1-ol; In acetonitrile; at 0 - 20 ℃;

With hydrazine hydrate; In acetonitrile; at 0 - 20 ℃; for 5h;

upstream raw materials:

ethyl-2-picolinate

morpholino(pyridin-2-yl)methanethione

methyl pyridine-2-carboxylate

2-Picolinic acid

Downstream raw materials:

5,6-diphenyl-3-(2-pyridyl)-1,2,4-triazine

(E)-N’-(2-hydroxybenzylidene)picolinohydrazone

3-mercapto-4-benzyl-5-(pyridin-2-yl)-1,2,4-triazole

1-(2-pyridyl)-5,6-dimethoxy-8-(benzyloxy)isoquinoline

Refernces

• 1、 Fu, Haoran,Liu, Haiyang,Zhao, Lei,Xiao, Boren,Fan, Tingting,Jiang, Yuyang. "A quinoline-based selective ‘turn on’ chemosensor for zinc(II) via quad-core complex, and its application in live cell imaging". . . Retrieved 2019.
• 2、 Mondal, Arpan,Konar, Sanjit. "Strong Equatorial Crystal Field Enhances the Axial Anisotropy and Energy Barrier for Spin Reversal Process in Yb2 Single Molecule Magnets". . p. 3449 - 3456. Retrieved 2021.
• 3、 Cai, Xinping,Huang, Ai,Huang, Jiaqi,Huang, Shoushun,Peng, Huanan,Peng, Xiaoming,Xu, Shujuan,Zhou, Jingjing. "Synthesis and crystal structure of a novel pyridine acylhydrazone derivative as a “turn on” fluorescent probe for Al3+". . . Retrieved 2020.
• 4、 Xu, Tingting,Huang, Junjie,Fang, Min,Sui, Mingshuai,Zhu, Yujing,Shentu, Yupeng,Li, Cun,Zhu, Weiju. "A novel turn-on fluorescent probe based on naphthalimide for the tracking of lysosomal Cu2+in living cells". . p. 21167 - 21175. Retrieved 2020.
• 5、 Zoufaly, Pavel,?i?már, Erik,Kuchár, Juraj,Herchel, Radovan. "The structural and magnetic properties of FeII and CoII complexes with 2-(furan-2-yl)-5-pyridin-2-yl-1,3,4-oxadiazole". . . Retrieved 2020.
• 6、 Hegde, Pooja,Boshoff, Helena I.M.,Rusman, Yudi,Aragaw, Wassihun Wedajo,Salomon, Christine E.,Dick, Thomas,Aldrich, Courtney C.. "Reinvestigation of the structure-activity relationships of isoniazid". . . Retrieved 2021.
• 7、 Aggarwal,Rao. "-". . p. 59,60. Retrieved 1977.
• 8、 Puttock, Emma V.,Sturala, Jiri,Kistemaker, Jos C. M.,Williams, J. A. Gareth. "Platinum(II) Complexes of Tridentate N∧N- ∧N -Coordinating Ligands Based on Imides, Amides, and Hydrazides: Synthesis and Luminescence Properties". . p. 335 - 347. Retrieved 2021.
• 9、 Al-Daher, Abdul Ghany M.,Alfares, Amenah A.,Alnuaimy, Lana A.. "Synthesis and Characterization of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes with 2-Carboxy benzaldehyde Aroylhydrazones". . p. 271 - 278. Retrieved 2022/01/22.
• 10、 Liu, Jie,Zhang, Guang-Yu,Zhang, Zhe,Li, Bo,Chai, Fei,Wang, Qi,Zhou, Zi-Dan,Xu, Ling-Ling,Wang, Shou-Kai,Jin, Zhen,Tang, You-Zhi. "Design, synthesis, in vitro and in vivo evaluation against MRSA and molecular docking studies of novel pleuromutilin derivatives bearing 1, 3, 4-oxadiazole linker". . . Retrieved 2021/05/17.