1-Chlorocarbonyl-4-piperidinopiperidine hydrochloride

Base Information

• Chemical Name: 1-Chlorocarbonyl-4-piperidinopiperidine hydrochloride
• CAS No.: 143254-82-4
• Molecular Formula: C₁₁H₁₉ClN₂O*ClH
• Molecular Weight: 267.199
• Hs Code.: 2933399090
• European Community (EC) Number: 686-744-2
• DSSTox Substance ID: DTXSID20469837
• Mol file: 143254-82-4.mol

Synonyms:1-Chlorocarbonyl-4-piperidinopiperidine hydrochloride;143254-82-4;1,4'-Bipiperidine-1'-carbonyl chloride hydrochloride;1-Chlorocarbonyl-4-piperidinopiperidine HCl;MFCD08445613;4-piperidin-1-ylpiperidine-1-carbonyl chloride;hydrochloride;1-Chlorocarbonyl-4-piperidinopiperidine, HCl;VBXXNCHZAMNCBX-UHFFFAOYSA-N;1-Chlorocarbonyl-4-piperidinopiperidinehydrochloride;[1,4'-Bipiperidine]-1'-carbonyl chloride, monohydrochloride;1,4'-Bipiperidine-1-carboxylic chloride HCl;[1,4'-bipiperidine]-1'-carbonyl chloride hcl;SCHEMBL457517;DTXSID20469837;1-(Chlorocarbonyl)-4-(piperidin-1-yl)piperidine hydrochloride;BCP22911;AKOS015845791;AC-1853;CS-W021318;SB41063;AS-11433;SY104196;FT-0600370;F20465;J-504526;[1,4']bipiperidinyl-1'-carbonyl chloride hydrochloride;F1967-1583;[1,4 inverted exclamation mark -Bipiperidine]-1 inverted exclamation mark -carbonyl Chloride Hydrochloride

Chemical Property of 1-Chlorocarbonyl-4-piperidinopiperidine hydrochloride

Chemical Property:

• Appearance/Colour: power
• Vapor Pressure: 6.57E-05mmHg at 25°C
• Boiling Point: 344.5 °C at 760 mmHg
• Flash Point: 162.1 °C
• PSA: 23.55000
• LogP: 2.97330
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 266.0952687
• Heavy Atom Count: 16
• Complexity: 221

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Chlorocarbonyl-4-piperidinopiperidinehydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/38
• Safety Statements: 26-28

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)C2CCN(CC2)C(=O)Cl.Cl

Technology Process of 1-Chlorocarbonyl-4-piperidinopiperidine hydrochloride

There total 2 articles about 1-Chlorocarbonyl-4-piperidinopiperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

bis(trichloromethyl) carbonate (32315-10-9) + 4-piperidinopiperidine hydrochloride (172281-92-4,4876-60-2) → 4-piperidinopiperidine-1-carbonyl chloride hydrochloride (143254-82-4)

Guidance literature:

bis(trichloromethyl) carbonate; In dichloromethane; for 0.5h; Inert atmosphere;

4-piperidinopiperidine hydrochloride; In dichloromethane; at 5 - 30 ℃; for 4.5h; Inert atmosphere;

Reference yield: 85.5%

4-piperidinopiperidin (4897-50-1) + bis(trichloromethyl) carbonate (32315-10-9) → 4-piperidinopiperidine-1-carbonyl chloride hydrochloride (143254-82-4)

Guidance literature:

In dichloromethane;

Reference yield:

4-piperidinopiperidine-1-carbonyl chloride hydrochloride (143254-82-4) + (S)-10-hydroxycamptothecin (19685-09-7,64439-81-2) → 10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (103816-16-6)

Guidance literature:

With potassium carbonate; In acetonitrile; at 60 ℃; for 6h; Reagent/catalyst;

upstream raw materials:

4-piperidinopiperidin

bis(trichloromethyl) carbonate

4-piperidinopiperidine hydrochloride

Downstream raw materials:

10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin

Refernces

• 1、 -. "PROCESS FOR THE MANUFACTURE OF IRINOTECAN HYDROCHLORIDE BY TOTAL SYNTHESIS". Page/Page column 9. . Retrieved 2012/03/27.
• 2、 -. "AN IMPROVED PROCESS FOR THE PREPARATION OF IRINOTECAN HYDROCHLORIDE TRIHYDRATE". Page/Page column 9. . Retrieved 2010/10/20.