103816-16-6 Usage
Description
11-Desethyl Irinotecan is a derivative of the chemotherapeutic agent Irinotecan, which is a DNA topoisomerase inhibitor. It is an impurity found in the pharmaceutical compound Irinotecan (I767500) and has potential applications in the field of cancer treatment.
Uses
Used in Pharmaceutical Industry:
11-Desethyl Irinotecan is used as an impurity in the production of Irinotecan, a DNA topoisomerase inhibitor. It plays a role in the development and formulation of the chemotherapeutic drug, which is utilized for the treatment of various types of cancer.
Used in Cancer Treatment:
11-Desethyl Irinotecan is used as a component in the development of cancer treatment strategies, particularly those involving Irinotecan. It may contribute to the overall effectiveness of the treatment by interacting with the DNA topoisomerase enzyme, which is essential for DNA replication and transcription. By inhibiting this enzyme, 11-Desethyl Irinotecan, along with Irinotecan, can potentially lead to the disruption of cancer cell growth and proliferation.
Used in Research and Development:
11-Desethyl Irinotecan is also used in the research and development of new cancer treatments and drug formulations. Its presence in Irinotecan may provide valuable insights into the mechanisms of action and potential side effects of the drug, allowing for the optimization of treatment protocols and the development of more effective therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 103816-16-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,8,1 and 6 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 103816-16:
(8*1)+(7*0)+(6*3)+(5*8)+(4*1)+(3*6)+(2*1)+(1*6)=96
96 % 10 = 6
So 103816-16-6 is a valid CAS Registry Number.
103816-16-6Relevant articles and documents
PODOPHYLLOTOXIN DERIVATIVES AND THEIR USE
-
Paragraph 0115; 0117, (2017/05/15)
Provided herein are compounds, compositions, and methods for treating cancer in a subject in need thereof.
Synthesis and evaluation of a DHA and 10-hydroxycamptothecin conjugate
Wang, Yuqiang,Li, Lianfa,Jiang, Wei,Larrick, James W.
, p. 5592 - 5599 (2007/10/03)
We have synthesized a conjugate of cis-4,7,10,13,16,19-docosahexenoic acid (DHA) and 10-hydroxycamptothecin (HCPT), DHA-HCPT. The antitumor activity of DHA-HCPT was evaluated in vitro against L1210 leukemia cells and in experimental animal tumor models in