2-(Methylamino)benzaldehyde

Base Information

• Chemical Name: 2-(Methylamino)benzaldehyde
• CAS No.: 7755-70-6
• Molecular Formula: C8H9 N O
• Molecular Weight: 135.166
• Hs Code.: 2922399090
• European Community (EC) Number: 837-326-5
• NSC Number: 106926
• DSSTox Substance ID: DTXSID30296015
• Nikkaji Number: J81.448B
• Wikidata: Q82036310
• Mol file: 7755-70-6.mol

Synonyms:2-(methylamino)benzaldehyde;7755-70-6;NSC106926;methylaminobenzaldehyde;N-methylaminobenzaldehyde;2-Methylamino-benzaldehyde;SCHEMBL874034;SCHEMBL19726078;DTXSID30296015;LIZGLUQDMOJDMM-UHFFFAOYSA-N;MFCD19216814;AKOS006347239;CS-W021444;DS-6317;NSC-106926;EN300-332093;O10528;A865197;Z1203730947

Chemical Property of 2-(Methylamino)benzaldehyde

Chemical Property:

• Vapor Pressure: 0.0121mmHg at 25°C
• Boiling Point: 260.7°Cat760mmHg
• PKA: 2.96±0.10(Predicted)
• Flash Point: 121.3°C
• PSA: 29.10000
• Density: 1.121g/cm³
• LogP: 1.61380
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 135.068413911
• Heavy Atom Count: 10
• Complexity: 114

Purity/Quality:

99%, ^*data from raw suppliers

2-(METHYLAMINO)BENZALDEHYDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC1=CC=CC=C1C=O

Technology Process of 2-(Methylamino)benzaldehyde

There total 33 articles about 2-(Methylamino)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

anthranil (271-58-9) + methyllithium (917-54-4) → 2-(methylamino)benzaldehyde (7755-70-6)

Guidance literature:

methyllithium; With zinc(II) chloride; In tetrahydrofuran; at -78 - 20 ℃;

anthranil; bis(acetylacetonate)nickel(II); In tetrahydrofuran;

DOI:10.1039/b511998g

Reference yield: 87.0%

N-methylquinolinium iodide (3947-76-0) → 2-(methylamino)benzaldehyde (7755-70-6)

Guidance literature:

With dihydrogen peroxide; potassium hydroxide; In water; 1,2-dichloro-ethane; at 0 - 20 ℃;

DOI:10.1002/chem.202005246

Reference yield: 85.0%

2--benzaldehyd (7755-71-7) → 2-(methylamino)benzaldehyde (7755-70-6)

Guidance literature:

With triethylsilane; iodine; In dichloromethane; at 20 ℃; for 0.166667h;

DOI:10.1002/adsc.201701047

upstream raw materials:

anthranil

dimethyl sulfate

o-aminobenzaldehyde

sodium diethylmalonate

Downstream raw materials:

N-methyl-N-geranyl-2-aminobenzaldehyde

2-(methyl(3-methylbut-2-en-1-yl)amino)benzaldehyde

N-(2-formylphenyl)-N,4-dimethylbenzenesulfonamide

neocryptolepine

Refernces

• 1、 Algoazy, Nawaf,Knight, Julian G.,Waddell, Paul G.,Aerts, Roy,Herrebout, Wouter,Al-Sharif, Hatun H. T.,Karlsson, Joshua K. G.,Harriman, Anthony. "Synthesis, Structure and Photophysical Properties of a New Class of Inherently Chiral Boron(III) Chelates—The tert-Leucine Complexes". supporting information. p. 5246 - 5258. Retrieved 2021/02/26.
• 2、 -. "Preparation method and application of new theophylline boric acid compound". Paragraph 0013-0016; 0018. . Retrieved 2021/09/01.