4-Methoxyphenylphosphonic Dichloride

Base Information

• Chemical Name: 4-Methoxyphenylphosphonic Dichloride
• CAS No.: 37632-18-1
• Molecular Formula: C7H7 Cl2 O2 P
• Molecular Weight: 225.011
• Hs Code.: 2931900090
• European Community (EC) Number: 672-689-1
• DSSTox Substance ID: DTXSID60191069
• Nikkaji Number: J53.775F
• Wikidata: Q83063558
• Mol file: 37632-18-1.mol

Synonyms:4-Methoxyphenylphosphonic Dichloride;37632-18-1;1-dichlorophosphoryl-4-methoxybenzene;4-Dichlorophosphonylanisole;BRN 2937079;Phosphonic dichloride, (p-methoxyphenyl)-;(p-Methoxyphenyl)phosphonic dichloride;Phosphonic dichloride, (4-methoxyphenyl)-;4-16-00-01112 (Beilstein Handbook Reference);(4-methoxyphenyl)phosphonic dichloride;C7H7Cl2O2P;SCHEMBL2212578;C7-H7-Cl2-O2-P;DTXSID60191069;4-methoxyphenyl phosphonic dichloride;MFCD00123296;4-Methoxyphenyldichlorophosphine oxide;(4-methoxyphenyl)phosphonoyl dichloride;4-METHOXYPHENYLPHOSPHONICDICHLORIDE;LS-106859;FT-0725971;M1156;T72387

Chemical Property of 4-Methoxyphenylphosphonic Dichloride

Chemical Property:

• Vapor Pressure: 0.00202mmHg at 25°C
• Refractive Index: 1.5700-1.5740
• Boiling Point: 300.3 °C at 760 mmHg
• Flash Point: 174.5 °C
• PSA: 36.11000
• Density: 1.39 g/cm³
• LogP: 2.99120
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 223.9560718
• Heavy Atom Count: 12
• Complexity: 184

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Methoxyphenylphosphonic Dichloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)P(=O)(Cl)Cl

Technology Process of 4-Methoxyphenylphosphonic Dichloride

There total 6 articles about 4-Methoxyphenylphosphonic Dichloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dichloro-4-methoxyphenylphosphine (19909-85-4) → 4-methoxyphenylphosphonic dichloride (37632-18-1)

Guidance literature:

With sulfuryl dichloride; chlorobenzene;

Reference yield:

methoxybenzene (100-66-3) → 4-methoxyphenylphosphonic dichloride (37632-18-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / PCl₃ / Lewis acid

2: DMSO / CH₂Cl₂ / 0.5 h / -76 °C

With dimethyl sulfoxide; phosphorus trichloride; Lewis acid; In dichloromethane;

Reference yield:

tetrachloro-(4-methoxy-phenyl)-phosphorane (64955-93-7) → 4-methoxyphenylphosphonic dichloride (37632-18-1)

Guidance literature:

With sulfur dioxide;

upstream raw materials:

dichloro-4-methoxyphenylphosphine

tetrachloro-(4-methoxy-phenyl)-phosphorane

diethyl (p-methoxyphenyl)phosphonate

methoxybenzene

Downstream raw materials:

diisopropyl (p-methoxyphenyl)phosphonate

O,O-dimethyl (4-methoxyphenyl)phosphonothioate

(4-methoxyphenyl)phosphonic acid bis(2,2,2-trifluoroethyl) ester

(4-methoxyphenyl)phosphonic acid

Refernces

• 1、 Grabiak, Raymond C.,Miles, James A.,Schwenzer, Gretchen M.. "SYNTHESIS OF PHOSPHONIC DICHLORIDES AND CORRELATION OF THEIR P-31 CHEMICAL SHIFTS". . p. 197 - 202. Retrieved 2007/10/02.