4-Methoxyphenylphosphonic acid

Base Information

• Chemical Name: 4-Methoxyphenylphosphonic acid
• CAS No.: 21778-19-8
• Molecular Formula: C7H9 O4 P
• Molecular Weight: 188.12
• Hs Code.: 2931900090
• European Community (EC) Number: 633-663-5
• DSSTox Substance ID: DTXSID60381448
• Nikkaji Number: J282.334I
• Wikidata: Q82172271
• Mol file: 21778-19-8.mol

Synonyms:4-methoxyphenylphosphonic acid;21778-19-8;(4-methoxyphenyl)phosphonic Acid;Hydrogen 4-Methoxyphenylphosphonate;4-Phosphonylanisole;SCHEMBL233806;4-methoxybenzenephosphonic acid;(4-methoxyphenyl)phosphonicAcid;DTXSID60381448;(4-methoxyphenyl)-phosphonic acid;MFCD00013948;AKOS015962558;4-methoxyphenyl phosphonic acid, 98 %;AS-60973;Benzene, 1-chloro-2-(1-propyn-1-yl)-;CS-0315044;FT-0618961;M1155;T72088

Chemical Property of 4-Methoxyphenylphosphonic acid

Chemical Property:

• Vapor Pressure: 1.18E-06mmHg at 25°C
• Melting Point: 47-52?°C(lit.)
• Refractive Index: 1.555
• Boiling Point: 386.2°C at 760 mmHg
• PKA: pK1:2.4;pK2:7.15 (17°C)
• Flash Point: 187.4°C
• PSA: 76.57000
• Density: 1.4g/cm³
• LogP: 0.49820
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 188.02384576
• Heavy Atom Count: 12
• Complexity: 180

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Methoxyphenylphosphonic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)P(=O)(O)O

Technology Process of 4-Methoxyphenylphosphonic acid

There total 19 articles about 4-Methoxyphenylphosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

diethyl (p-methoxyphenyl)phosphonate (3762-33-2) → (4-methoxyphenyl)phosphonic acid (21778-19-8)

Guidance literature:

With hydrogenchloride; Heating;

DOI:10.1055/s-1990-26813

Reference yield: 100.0%

bis(trimethylsilyl)-p-methoxyphenylphosphonate (136560-20-8) → (4-methoxyphenyl)phosphonic acid (21778-19-8)

Guidance literature:

With methanol; for 24h; Ambient temperature;

DOI:10.1007/BF00863831

Reference yield: 66.0%

Lawessons reagent (19172-47-5,94367-93-8) → (4-methoxyphenyl)phosphonic acid (21778-19-8)

Guidance literature:

With water; In acetonitrile; for 0.0833333h; Reflux;

DOI:10.1021/jo101865y

upstream raw materials:

Lawessons reagent

dichloro-4-methoxyphenylphosphine

4-methoxyphenylphosphonic dichloride

4-methoxy-aniline

Downstream raw materials:

(4-methoxy-3-nitro-phenyl)-phosphonic acid

E-1-(phenyl)-2-(4'-methoxyphenyl)ethene

(E)-4-chloro-4'-methoxystilbene

tert-butyl (E)-3-(4-methoxyphenyl)prop-2-enoate

Refernces

• 1、 Aragoni, M. Carla,Arca, Massimiliano,Blake, Alexander J.,Lippolis, Vito,Schroeder, Martin,Wilson, Claire. "4-methoxyphenylphosphonic acid: Reactivity of Lawesson's reagent". . p. o260-o262. Retrieved 2002.
• 2、 Cai, Zhong-Sheng,Hoshino, Norihisa,Bao, Song-Song,Jia, Jiage,Akutagawa, Tomoyuki,Zheng, Li-Min. "Dynamic Motion of Organic Ligands in Polar Layered Cobalt Phosphonates". . p. 13495 - 13503. Retrieved 2018/09/19.
• 3、 Leypold, Mario,Wallace, Paal W.,Kljajic, Marko,Schittmayer, Matthias,Pletz, Jakob,Illaszewicz-Trattner, Carina,Guebitz, Georg M.,Birner-Gruenberger, Ruth,Breinbauer, Rolf. "A robust and simple protocol for the synthesis of arylfluorophosphonates". supporting information. p. 5619 - 5622. Retrieved 2015/09/21.