2-(4-Methoxyphenoxy)ethylamine

Base Information

• Chemical Name: 2-(4-Methoxyphenoxy)ethylamine
• CAS No.: 50800-92-5
• Molecular Formula: C9H13NO2
• Molecular Weight: 167.208
• Hs Code.: 2922299090
• European Community (EC) Number: 672-841-7
• Mol file: 50800-92-5.mol

Synonyms:2-(4-Methoxyphenoxy)ethylamine;50800-92-5;2-(4-methoxyphenoxy)ethanamine;2-(4-Methoxyphenoxy)-1-ethanamine;Ethanamine, 2-(4-methoxyphenoxy)-;MFCD00052978;2-(4-methoxyphenoxy)ethan-1-amine;1-(2-Aminoethoxy)-4-Methoxybenzene;2-(4-methoxy-phenoxy)-ethylamine;Maybridge3_000601;4-methoxy phenoxyethylamine;Oprea1_443993;SCHEMBL321542;2-(4-methoxy-phenoxy)ethylamine;2-(4-methoxyphenoxy) ethylamine;YXRCDWIZAGWUBL-UHFFFAOYSA-N;2-(4-methoxyphenyloxy)ethyl amine;2-(4-methoxyphenyloxyl)ethyl amine;AMY20108;STK523739;AKOS000201022;IDI1_011988;SY008273;2-(4-methoxyphenoxy)ethylamine, AldrichCPR;A7525;CS-0117201;FT-0608665;EN300-14637;[2-(4-methoxyphenoxy)ethyl]amine hydrochloride;12X-0806;J-506035;Z54845983

Chemical Property of 2-(4-Methoxyphenoxy)ethylamine

Chemical Property:

• Vapor Pressure: 0.00317mmHg at 25°C
• Melting Point: 38-40 °C
• Refractive Index: 1.518
• Boiling Point: 283.4 °C at 760 mmHg
• PKA: 8.24±0.10(Predicted)
• Flash Point: 136 °C
• PSA: 44.48000
• Density: 1.06 g/cm³
• LogP: 1.73300
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility.: Chloroform (Slightly), DMSO (Slightly)
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 167.094628657
• Heavy Atom Count: 12
• Complexity: 111

Purity/Quality:

98%min ^*data from raw suppliers

2-(4-Methoxyphenoxy)ethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C,Xn
• Statements: 36/37/38-41-22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)OCCN
• Uses: 2-(4-Methoxyphenoxy)ethylamine can be used electrolyte for batteries.

Technology Process of 2-(4-Methoxyphenoxy)ethylamine

There total 9 articles about 2-(4-Methoxyphenoxy)ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

para-iodoanisole (696-62-8) + ethanolamine (141-43-5) → 2-(4-methoxyphenoxy)ethylamine (50800-92-5)

Guidance literature:

With 1-(2-methylhydrazine-1-carbonyl)isoquinoline 2-oxide; tetrabutylammomium bromide; copper(II) sulfate; sodium hydroxide; In ethanol; water; at 140 ℃; for 10h; Schlenk technique;

Reference yield: 89.0%

2-[2-(4-methoxyphenoxy)ethyl]-1H-isoindole-1,3(2H)-dione (321432-17-1) → 2-(4-methoxyphenoxy)ethylamine (50800-92-5)

Guidance literature:

With hydrazine hydrate; acetic acid; In methanol; for 4h; Reflux;

DOI:10.1016/j.bmc.2010.06.100

Reference yield: 81.0%

2-(tert-butoxycarbonylamino)ethyl bromide (39684-80-5) + 4-methoxy-phenol (150-76-5) → 2-(4-methoxyphenoxy)ethylamine (50800-92-5)

Guidance literature:

2-(tert-butoxycarbonylamino)ethyl bromide; 4-methoxy-phenol; With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 15h; Inert atmosphere;

With trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1039/c4ob00711e

upstream raw materials:

1-(2-bromoethoxy)-4-methoxybenzene

potassium phtalimide

2-(4-methoxyphenoxy)acetonitrile

2-[2-(4-methoxyphenoxy)ethyl]-1H-isoindole-1,3(2H)-dione

Downstream raw materials:

Alpha-isopropyl-alpha-[3-[N-[2-(4-methoxyphenoxy)ethyl]amino]-propyl]-3,4-dimethoxyphenylacetonitrile

C₂₅H₂₇NO₄

(E)-methyl 3-[2-(4-methoxyphenoxy)ethylamino]acrylate

(Z)-methyl 3-[2-(4-methoxyphenoxy)ethylamino]acrylate

Refernces

• 1、 -. "N-arylation method in aqueous phase system with substituted quinoline or isoquinoyl hydrazide pyridine-N-oxide as ligand". Paragraph 0060; 0061; 0062; 0063. . Retrieved 2019/03/28.
• 2、 Vettorazzi, Marcela,Angelina, Emilio,Lima, Santiago,Gonec, Tomas,Otevrel, Jan,Marvanova, Pavlina,Padrtova, Tereza,Mokry, Petr,Bobal, Pavel,Acosta, Lina M.,Palma, Alirio,Cobo, Justo,Bobalova, Janette,Csollei, Jozef,Malik, Ivan,Alvarez, Sergio,Spiegel, Sarah,Jampilek, Josef,Enriz, Ricardo D.. "An integrative study to identify novel scaffolds for sphingosine kinase 1 inhibitors". . p. 461 - 481. Retrieved 2017/08/21.