3-(Piperazin-1-yl)propan-1-amine

Base Information

• Chemical Name: 3-(Piperazin-1-yl)propan-1-amine
• CAS No.: 34885-02-4
• Molecular Formula: C7H17N3
• Molecular Weight: 143.232
• Hs Code.: 2933599090
• European Community (EC) Number: 252-270-6
• DSSTox Substance ID: DTXSID50188443
• Nikkaji Number: J29.033E
• Wikidata: Q27449783
• Mol file: 34885-02-4.mol

Synonyms:34885-02-4;3-(piperazin-1-yl)propan-1-amine;1-(3-Aminopropyl)piperazine;3-piperazin-1-ylpropan-1-amine;Piperazine-1-propylamine;EINECS 252-270-6;1-Piperazinepropylamine;(3-aminopropyl)piperazine;n-(3-aminopropyl)piperazine;3-(1-piperazinyl)propylamine;3-Piperazin-1-yl-propylamine;SCHEMBL234400;DTXSID50188443;MFCD00129013;AKOS005068291;CS-W007069;DS-5477;1-(3-aminopropyl)piperazine, AldrichCPR;A6128;FT-0604301;C74791;EN300-300488;Q27449783

Chemical Property of 3-(Piperazin-1-yl)propan-1-amine

Chemical Property:

• Vapor Pressure: 0.039mmHg at 25°C
• Refractive Index: 1.4974 (589.3 nm 25℃)
• Boiling Point: 240 °C at 760 mmHg
• PKA: 10.39±0.10(Predicted)
• Flash Point: 98.9 °C
• PSA: 41.29000
• Density: 0.946 g/cm³
• LogP: 0.20740
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: -1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 143.142247555
• Heavy Atom Count: 10
• Complexity: 78.9

Purity/Quality:

99% ^*data from raw suppliers

1-(3-Aminopropyl)piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1)CCCN

Technology Process of 3-(Piperazin-1-yl)propan-1-amine

There total 5 articles about 3-(Piperazin-1-yl)propan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-(3-benzyloxycarbonylamino-propyl)-piperazine-1-carboxylic acid benzyl ester (910127-07-0) → 3-(piperazin-1-yl)propan-1-amine (34885-02-4)

Guidance literature:

With hydrogen; palladium dihydroxide; In methanol; for 16h;

Reference yield:

piperazine (110-85-0) + acrylonitrile (107-13-1,25014-41-9) → 3-(piperazin-1-yl)propan-1-amine (34885-02-4) + 1,4-bis(3-aminopropyl)piperazine (7209-38-3)

Guidance literature:

With methanol; ammonia; nickel; at 90 ℃; under 102971 - 128714 Torr; Hydrogenation;

DOI:10.1021/ja01211a053

Reference yield:

piperazine (110-85-0) + propan-1-ol-3-amine (156-87-6) → 3-(piperazin-1-yl)propan-1-amine (34885-02-4)

Guidance literature:

With carbon dioxide; In water; at 220 ℃; for 4h; Sealed tube;

upstream raw materials:

piperazine

acrylonitrile

azetidine

4-(3-benzyloxycarbonylamino-propyl)-piperazine-1-carboxylic acid benzyl ester

Downstream raw materials:

C₈₈H₁₅₄N₁₆O₁₆

C₃₄H₃₉ClN₈O₂

Refernces

• 1、 -. "Inhibitors of aminoglycoside 6'-N-acetyltransferases, compositions and uses thereof". Page/Page column 17. . Retrieved 2008/06/13.
• 2、 Bobylev, V. A.,Veselkov, N. Yu.,Dalin, A. R.,Sharikov, F. Yu.. "NUCLEOPHILIC CLEAVAGE AND FORMATION OF SATURATED HETEROCYCLES. XII. REACTIVITY OF SMALL HETEROCYCLES TOWARD AMINOLYSIS AND HYDROLYSIS". . p. 1700 - 1713. Retrieved 2007/10/02.