2-Thiophenecarboxylic acid, 4-nitro-5-[(1E)-2-phenylethenyl]-, methyl ester

Base Information

• Chemical Name: 2-Thiophenecarboxylic acid, 4-nitro-5-[(1E)-2-phenylethenyl]-, methyl ester
• CAS No.: 42747-98-8
• Molecular Formula: C14H11NO4S
• Molecular Weight: 289.312
• Mol file: 42747-98-8.mol

Synonyms:

Chemical Property of 2-Thiophenecarboxylic acid, 4-nitro-5-[(1E)-2-phenylethenyl]-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Thiophenecarboxylic acid, 4-nitro-5-[(1E)-2-phenylethenyl]-, methyl ester

There total 10 articles about 2-Thiophenecarboxylic acid, 4-nitro-5-[(1E)-2-phenylethenyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

5-methyl-4-nitro-thiophene-2-carboxylic acid methyl ester (56921-01-8) + benzaldehyde (100-52-7) → 4-nitro-5-trans-styryl-thiophene-2-carboxylic acid methyl ester (42747-98-8)

Guidance literature:

5-methyl-4-nitro-thiophene-2-carboxylic acid methyl ester; benzaldehyde; In methanol; Heating / reflux;

pyrrolidine; In methanol; for 58h; Heating / reflux;

Reference yield:

1-bromodibenzo[b,d]furan (50548-45-3) → 4-nitro-5-trans-styryl-thiophene-2-carboxylic acid methyl ester (42747-98-8)

Guidance literature:

With diethyl ether; magnesium; anschliessend Behandeln mit festem Kohlendioxid;

DOI:10.1021/ja01875a013

Reference yield:

4-aminodibenzofuran (50548-43-1) → 4-nitro-5-trans-styryl-thiophene-2-carboxylic acid methyl ester (42747-98-8)

Guidance literature:

Multi-step reaction with 5 steps

1: benzene

2: acetic acid; bromine

3: ethanolic KOH-solution

4: NaNO₂; HCl; hypophosphoric acid

5: magnesium; diethyl ether / anschliessend Behandeln mit festem Kohlendioxid

With hydrogenchloride; potassium hydroxide; diethyl ether; bromine; hypophosphoric acid; magnesium; acetic acid; sodium nitrite; benzene;

DOI:10.1021/ja01875a013

upstream raw materials:

1-bromodibenzo[b,d]furan

5-methyl-4-nitro-thiophene-2-carboxylic acid methyl ester

benzaldehyde

1-methyl-dibenzofuran

Downstream raw materials:

5-phenyl-4H-thieno[3,2-b]pyrrole-2-carboxylic acid methyl ester

2-Benzylidenmethyl-3-nitro-5-thiophen-carbonsaeure

Refernces