Cyclohexaneacetic acid, 4-phenyl-, trans-

Base Information

• Chemical Name: Cyclohexaneacetic acid, 4-phenyl-, trans-
• CAS No.: 52092-29-2
• Molecular Formula: C14H18O2
• Molecular Weight: 218.29200
• Mol file: 52092-29-2.mol

Synonyms:

Chemical Property of Cyclohexaneacetic acid, 4-phenyl-, trans-

Chemical Property:

• PSA: 37.30000
• LogP: 3.43510

Purity/Quality:

≥95% ^*data from raw suppliers

Cyclohexaneaceticacid,4-phenyl-,trans- 98.45% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclohexaneacetic acid, 4-phenyl-, trans-

There total 18 articles about Cyclohexaneacetic acid, 4-phenyl-, trans- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-(4-phenylcyclohexyl)acetate (411238-92-1) → (trans)-2-(4-phenylcyclohexyl)acetic acid (52092-29-2) + (cis)-2-(4-phenylcyclohexyl)acetic acid (148962-93-0)

Guidance literature:

With water; lithium hydroxide; In ethanol; at 50 ℃; for 6h;

Reference yield:

formic acid (64-18-6) + 4-phenyl-1-methylenecyclohexane (87143-17-7) → (trans)-2-(4-phenylcyclohexyl)acetic acid (52092-29-2) + (cis)-2-(4-phenylcyclohexyl)acetic acid (148962-93-0)

Guidance literature:

With carbon monoxide; palladium diacetate; 1,4-di(diphenylphosphino)-butane; In 1,2-dimethoxyethane; at 150 ℃; for 16h; under 5168 Torr; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jo00065a028

Reference yield:

→ (trans)-2-(4-phenylcyclohexyl)acetic acid (52092-29-2) + (cis)-2-(4-phenylcyclohexyl)acetic acid (148962-93-0)

Guidance literature:

With ethanol; platinum; at 50 ℃; Hydrogenation_.Hydrolyse des erhaltenen Aethylesters;

upstream raw materials:

1-cyclohexenylacetic acid

cyclohexylideneacetic acid

trans-ethyl 2-4-((4-(hydroxymethyl)phenyl)cyclohexyl)acetate

formic acid

Downstream raw materials:

2trans-bicyclohexyl-4-ylmethyl-3-hydroxy-[1,4]naphthoquinone

trans-ethyl 2-4-((4-(hydroxymethyl)phenyl)cyclohexyl)acetate

(trans-4-phenyl-cyclohexyl)-acetic acid-chloride

Refernces

• 1、 -. "IMMUNOREGULATORY AGENTS". . . Retrieved 2016/01/27.
• 2、 Carenini,Carissimi,Gentili,Grumelli,Picciola,Ravenna. "Synthesis and pharmacological study of diphenylalkylamines with cycloaliphatic residues; new coronary vasodilators". . p. 2127 - 2136. Retrieved 2007/10/06.